The Department of Anesthesiology and Critical Care Medicine has continued its tradition of institutional discovery by leading the field in high impact research and remaining in the top 3 funded Departments in the country. Our portfolio of research is diverse and covers areas of research from the molecular mechanisms of neuroprotection to integrative medicine and operations research. We pride ourselves on being at the cutting edge in the traditional areas of basic and translational research. Moreover, we are proud to have trained and continue to train leaders in research in our field through rigorous didactic and mentored programs that are proven pathways to success. Our T32 NIH training program grant as well as other Departmental and Institutional resources are significant contributors to this success. The recent robust financial investment in internal grant support through our Stimulating and Advancing ACCM Research speaks to the seriousness with which we take the research mission and is already leading to profound growth in our discovery portfolio. Our collaborations with the Whiting School of Engineering, Carey Business School and Bloomberg School of Public Health not to mention other Departments at Hopkins and beyond speaks to the depth and breadth of what we are engaged in at Johns Hopkins ACCM research.