Clinical Research – Johns Hopkins Anesthesiology and Critical Care Medicine

ACCM faculty members and trainees in Clinical Research have access to core facilities and support that serve as a comprehensive resource for planning, conducting, and analyzing data for research endeavors. Clinical Research is supported by research nurse coordinators, research coordinators, a biostatistician, and a database manager. Areas of active investigation span multiple perioperative disciplines including outcomes after cardiac surgery, pediatrics, critical care, and pain management. The research structure provides ample support for investigator and industry-supported studies, including database acquisition and access, administrative assistance and IRB submission support.

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Our Core Team

Melania Bembea, MD, MPH, PhD
Director of Anesthesiology and Critical Care Medicine Clinical and Translational Research
Professor, Department of Anesthesiology and Critical Care Medicine

Josh Rudnicki, MBA
Senior Research Program Manager
Department of Anesthesiology and Critical Care Medicine

Colleen Mennie
Senior Research Nurse
Department of Anesthesiology and Critical Care Medicine

Kamala Simkhada
Senior Research Nurse
Department of Anesthesiology and Critical Care Medicine

Beth White
Senior Research Nurse
Department of Anesthesiology and Critical Care Medicine

ACCM Featured Research

Download Excel spreadsheet

	Our Researchers	Featured Research
	Ascenzi, Judy, DPN, RN Director, Johns Hopkins Children's Center of Pediatric Nursing Programs; Education, Informatics, and Research	Implementation of a Bedside Checklist to Improve Neurologic Outcomes of Post-Cardiac Arrest Patients in a Pediatric Intensive Care Unit
	Austin, Matt, PhD Associate Professor, Anesthesiology and Critical Care Medicine	Further Maturation of a Partially-Developed Performance Measure of Stroke Misdiagnosis in Hospital Emergency Departments
	Banks, Michael, MD, MEHP Assistant Professor, Anesthesiology and Critical Care Medicine	Development of a New Inter-professional Education/Collaborative Practice Questionnaire
	Barnes, Sean, MD, MBA Assistant Professor, Anesthesiology and Critical Care Medicine	Association of Biomarkers and Postoperative Delirium in Children After Cardiac Bypass Surgery A Retrospective Analysis of Intraoperative Blood Glucose Levels and Monitoring Frequencies in Pediatric Patients Undergoing Cardiopulmonary Bypass Surgeries
	Bembea, Melania, MD, PhD, MPH Director, ACCM Clinical Translational Research Program Professor, Anesthesiology and Critical Care Medicine	Biomarkers of Brain Injury in Critically-Ill Children on Extracorporeal Membrane Oxygenation (BEAM) Immunology of Influenza Critical Illness in Young People (PICFLU2)
	Booth, Lauren MSN, CRNP, PNP-AC Senior Nurse Practitioner Johns Hopkins Pediatric Intensive Care Unit (PICU)	Improving Time to Antibiotic Administration in the Pediatric Intensive Care Unit
	Chari, Asha, MD Clinical Associate, Anesthesiology and Critical Care Medicine	Using Perioperative Code Simulation to Improve Teamwork
	Chin, Laura, MD, MPH Assistant Professor, Anesthesiology and Critical Care Medicine	Perspectives and barriers of Pediatric Anesthesiologists And Intensivists to learning point of care ultrasound (POCUS)
	Chinedozi, Ima, MD, MPH Assistant Professor, Anesthesiology and Critical Care Medicine	Competency and Optimization in Medical Oxygen Therapy (COMET-O2)
	Cho, Brian, MD Assistant Professor, Anesthesiology and Critical Care Medicine	Discharge hemoglobin levels after cardiac surgery and 30-day readmission rates. Antithrombin-3 levels in multi-level spine surgeries and perioperative thrombotic events.
	Cho, Sung-Min, DO, MHS Associate Professor, Anesthesiology and Critical Care Medicine – Neuroscience Critical Care	SAfety and FEasibility of portable Magnetic Resonance Imaging in ECMO (SAFE MRI ECMO study) Assessing Acute Brain Injury after Rapid Reduction of PaCO2 upon ECMO Cannulation using Portable MRI and Biomarkers (DELTA ECMO ABI study)
	Dalesio, Nick, MD Associate Professor, Anesthesiology and Critical Care Medicine – Otolaryngology-Head and Neck Surgery	Using Machine Learning to Improve Accuracy in Allocating OR Block Time The Project SPRUCE Forest
	Das, Sam, PhD Associate Professor, Anesthesiology and Critical Care Medicine – Pathology	Exosome-based Non-traditional Technologies Towards Multi-Parametric and Integrated Approaches for SARS-CoV-2
	Dodd-o, Jeffrey, MD, PhD Associate Professor, Anesthesiology and Critical Care Medicine – Surgery	Exploring an association between elastography and outcome following heart or liver procedures Evaluation of the Efficacy of CVSICU Protocol for Reversing Neuromuscular Blockade
	Edwards, Lori-Ann, MBBS Assistant Program Director, Anesthesiology Residency Assistant Professor, Anesthesiology and Critical Care Medicine	Quantitative Electromyography train-of-four monitoring in children: a pilot randomized controlled study
	Engineer, Lilly, MD, DrPH Associate Director, Doctor of Public Health (DrPH) Program, Department of Health Policy and Management Assistant Professor, Anesthesiology and Critical Care Medicine	The aim of this proposal is to measure the use of diabetes medications at specified time intervals before and after bariatric surgery. Johns Hopkins healthcare system Emergency Preparedness
	Fackler, Jim, MD Professor, Anesthesiology and Critical Care Medicine	Anesthesia and Critical Care Medicine Precision Medicine Analytical Platform (ACCM-PMAP) Pediatric Critical Care Data Collaborative: Multi-institutional De-identified Data Aggregation for Collaborative Analysis
	Faraday, Nauder, MD, MPH Director, Perioperative Genomic and Translational Research, Perioperative Hemostasis and Thrombosis Research Professor, Anesthesiology and Critical Care Medicine	Reducing readmission rates to surgical ICUs at Johns Hopkins Hospital Derivation of novel features from time series physiologic data to identify and predict risk of adverse outcomes in high risk surgical patients
	Flavahan, Nicholas, PhD Professor, Anesthesiology and Critical Care Medicine	Cutaneous vascular cell communication
	Frank, Steven, MD Professor, Anesthesiology and Critical Care Medicine Chief of the Division of Adult Anesthesiology	Intravenous Iron is Superior to Red Cell Transfusions for Preoperative Iron Deficiency Anemia: A Propensity Matched Cohort Study Database Review to Assess Blood and Blood Product Utilization at The Johns Hopkins Hospitals
	Gao, Wei, MD Professor, Anesthesiology and Critical Care Medicine	Heart Failure with Preserved Ejection Fraction (HFpEF) Phenotypes and Postoperative Outcomes in Cardiac Surgery.
	Geocadin, Romer, MD Professor, Anesthesiology and Critical Care Medicine – Neurology, Neurosurgery	An Observational study of Somatosensory Evoked Potentials and Electroencephalography in Comatose Patients
	Goeddel, Lee, MD, MPH, FCCM Associate Professor, Anesthesiology and Critical Care Medicine	Pre-Operative AMPAC Score as a Predictor of Post-Operative Outcomes and Functional Capacity Association of left ventricular diastolic dysfunction to acute kidney injury after noncardiac surgery (DDAPKI study)
	Goswami, Dheeraj, MD Director, Pediatric Cardiac Anesthesia Associate Professor, Anesthesiology and Critical Care Medicine	Race and Its Effects on Perioperative Blood Transfusions for Pediatric Cardiac Surgery CHIlled Platelet Study (CHIPS)
	Gurses, Ayse, PhD Director, Armstrong Inst. Center for Health Care Human Factors Professor, Anesthesiology and Critical Care Medicine	Realtime Measurement of Situational Workload in NICU Clinicians to Improve Workload Management, Care Quality, and Patient Safety Patient-Centric Risk Model for Medication Safety During Care Transitions
	Hensley, Nadia, MD Director ACCM Quality, Safety and Service Associate Professor, Anesthesiology and Critical Care Medicine	Acute Normovolemic Hemodilution: A Prospective, Observational Study of the Volume Effect on Transfusions, Coagulation Mechanisms and Safety Outcomes Perioperative Plasma in Addition to Red Blood Cell Transfusions are Associated with Increased Venous Thromboembolism Risk Postoperatively
	Hoops, Katherine, MD, JD, MPH Associate Professor, Anesthesiology and Critical Care Medicine	ACTFAST: Pediatric Trauma Centers RE-AIM at Gun Safety ACTFAST: Urban and Rural Trauma Centers RE-AIM at Firearm Safety
	Horvath, Catherine, DNP, CRNA Program Director and Assistant Professor, Nurse Anesthesiology DNP Program	Effect of Resilience on Post Operative Pain in Geriatric Surgery Usability and Adoption of WikiAnesthesia with correlation to the Technology Acceptance Model
	Hunsberger, Joann, MD, MS Associate Professor, Anesthesiology and Critical Care Medicine	Scoliosis Outcomes Database Registry Pediatric palliative medicine, pediatric acute pain medicine, and pediatric anesthesia involvement in end of life care
	Hunt, Betsy, MD, MPH, PhD Co-Chair, Johns Hopkins CPR Advisory Committee Professor, Anesthesiology and Critical Care Medicine	Personalizing Outcomes after Child Cardiac Arrest (POCCA) Resuscitation Smart Board
	Johns, Roger, MD, MHS, PhD Professor, Anesthesiology and Critical Care Medicine	DAMP Signaling Mediates HIMF-induced Pulmonary Hypertension
	Kannan, Sujatha, MBBS Richard J. Traystman Endowed Chair Vice Chair for Research, Anesthesiology and Critical Care Medicine Professor, Anesthesia and Critical Care Medicine	Pediatric Research of Drugs, Immunoparalysis and Genetics during MODS (PARADIGM) Evaluation of the Kynurenine Pathway in Patients with Cerebral Palsy
	Koka, Rahul, MD Assistant Professor, Anesthesiology and Critical Care Medicine	The role of a Telepresence Robotics Program as a form of distraction therapy in pediatric preoperative patients Society for Pediatric Anesthesia National Adverse Event Database
	Kudchadkar, Sapna, MD, PhD Vice Chair, Pediatric ACCM Anesthesiologist-In-Chief, Johns Hopkins Children's Center Director, Johns Hopkins PICU Up! Program Professor, Anesthesiology and Critical Care Medicine	Clinical Effectiveness of the "PICU Up!" Multifaceted Early Mobility Intervention for Critically Ill Children: A pragmatic, stepped-wedge trial Protein optimization with exercise to improve muscle mass and functional outcomes (PROXIMUS) trial
	LaRosa, Jessica, MD Assistant Professor, Anesthesiology and Critical Care Medicine	Evaluation of a Simulation Curriculum to Improve Frequency and Safety of Nursing-Led Early Physical Rehabilitation of Critically Ill Children A Quality Improvement Project to Standardize High Flow Nasal Cannula Weaning in Bronchiolitis in the Pediatric Intensive Care Unit
	Laytin, Adam, MD, MPH Associate Professor, Anesthesiology and Critical Care Medicine – Emergency Medicine	Qualitative Assessment of the Pilot Implementation of a Locally Adapted ICU Registry Protocol in Addis Ababa, Ethiopia Case mix, processes of care, adverse events and clinical outcomes of intensive care units in Addis Ababa, Ethiopia
	Lee-Summers, Jennifer, MD Professor, Anesthesiology and Critical Care Medicine	The JHU Visiting Professor Exchange Cerebrovascular Autoregulation in Children At Risk for Neurologic Injury
	Lefebvre, Austen, MD Assistant Professor, Anesthesiology and Critical Care Medicine – Neurology	Equivalency Comparison Between Non-Invasive Laser Optical Holography-Derived Scalp Measurement of Intracranial Pressure (ICP) & Invasive ICP Catheter Recordings in a Cohort of Moderate-Severe Brain-Injured ICU Patients.
	Lester, Laeben, MD Assistant Professor, Anesthesiology and Critical Care Medicine	G-protein coupled sensory receptors in human heart and vascular tissue. A randomized controlled trial of an intervention to reduce the incidence of hypoxia with nasal CPAP versus standard care during procedural sedation for gastrointestinal endoscopy.
	Levin, Amanda, MD Program Director, Pediatric Critical Care Medicine Fellowship Associate Professor, Anesthesiology and Critical Care Medicine	Evaluation of ATLS compliance and teamwork during in situ pediatric trauma activations and recorded alpha trauma activations. Effectiveness of Pediatric Trauma Boot Camp curriculum at improving confidence of clinical fellows with the care of pediatric trauma patients.
	Mark, Lynette, MD Associate Professor, Anesthesiology and Critical Care Medicine Otolaryngology – Head and Neck Surgery	Comparison of the educational effectiveness of DAARC, a video game-blended e-learning system, and traditional written materials: A pilot study (2021)
	Mirski, Mark, MD, PhD Professor, Anesthesiology and Critical Care Medicine Neurology – Neurological Surgery	Real-Time Screening for Pulmonary Infection with digitalMALDI Analysis Equivalency Comparison Between Non-Invasive Laser Optical Holography-Derived Scalp Measurement of Intracranial Pressure (ICP) & Invasive ICP Catheter Recordings in a Cohort of Moderate-Severe Brain-Injured ICU Patients.
	Morad, Athir, MD Assistant Professor, Anesthesiology and Critical Care Medicine Neurology	Post Craniotomy Analgesia Safety Monitoring with ET CO2
	Muehlschlegel, Danny, MD, MMsc, MBA, FASA, FAHA Director (Chair) of the Department of Anesthesiology and Critical Care Medicine Professor, Anesthesiology and Critical Care Medicine	Gene Expression Profiling in Subjects With Postoperative Atrial Fibrillation After Cardiac Surgery TRanscriptomic ANalySis of left ventriCulaR gene Expression (TRANSCRibE)
	Nguyen, Ed, MD Assistant Professor, Anesthesiology and Critical Care Medicine	Trauma-Informed Anesthesia Care: Humanizing the Perioperative Process for Women with History of Sexual Assault Project GasCrowd: an online crowd-sourced, mobile-friendly database and communication tool for anesthesia practice guidelines
	Noje, Corina, MD Co-Director, JH Children's Center Pediatric Transport Program Associate Professor, Anesthesiology and Critical Care Medicine	Interhospital Transport of Children with Aspirated Foreign Bodies: A Single-Center Experience Optimizing interfacility transport response time for pediatric out-of-hospital cardiac arrest: A quality improvement intervention
	Nyquist, Paul, MD, FAHA, FCCM Professor, Neurology; Anesthesiology and Critical Care Medicine; Neurosurgery; General Internal Medicine	Cerebral regional oxygen saturation in sepsis using NIRS Continuous electro-encephalographic (cEEG) monitoring in the Intensive Care Unit: A survey of Intensive Care Units Worldwide
	O'Brien, Caitlin, MD, MPH Associate Director, JH Pediatric Neurocritical Care Program Associate Professor, Anesthesiology and Critical Care Medicine	Death One Hour After Terminal Extubation Study (DONATE) P-ICECAP: Pediatric Influence of Cooling duration on Efficacy in Cardiac Arrest Patients
	O'Conor, Katie, MD Research Associate, Anesthesiology and Critical Care Medicine	Trauma-Informed Care Education
	O'Neil, Pooja, MD, MBA Program Director, Pediatric Anesthesia Fellowship Assistant Professor, Anesthesiology and Critical Care Medicine	Chocolate or Sevoflurane? Use of Parosmia to Facilitate More Cooperative Inhalation Inductions in Children
	Phelps, Michael, MD Assistant Professor, Anesthesiology and Critical Care Medicine	Trends in ASATT exam participants and pass rates
	Pustavoitau, Aliaksei, MD, MHS Associate Professor, Anesthesiology and Critical Care Medicine	Perioperative predictors of liver transplant mortality, morbidity and economic outcomes Incorporation of structured focused transthoracic echocardiography (FOTE) learning into an existing critical care fellowship training program: a prospective study.
	Rivers, Richard, MD, PhD, MBA Associate Professor, Anesthesiology and Critical Care Medicine Ophthalmology	The Pain Experience of Pediatric Obstructive Sleep Apnea Patients that have Undergone a Corrective Tonsillectomy and Adenoidectomy
	Robertson, Courtney, MD Professor, Anesthesiology and Critical Care Medicine	Improving Pediatric Traumatic Brain Injury Outcomes Through Equitable Care Implementation Neurologic Manifestations of COVID 19 in Children
	Rollison, Sarah, DNP, CRNA Clinical Education Coordinator DNP Nurse Anesthesia track	Utilizing Simulation to Promote Medication Preparation and Administration Safety in Anesthesia
	Romer, Lewis, MD Professor, Anesthesiology and Critical Care Medicine Cell Biology Biomedical Engineering Pediatrics	Kids MoD PAH Trial: Mono- vs. Duo-Therapy for Pediatric Pulmonary Arterial Hypertension Unsettling Situations in the Pediatric Intensive Care Unit: A Curriculum for Improving Resident Confidence and Competence When Negotiating Emotionally Challenging Encounters
	Rosen, Michael, PhD Associate Professor, Anesthesiology and Critical Care Medicine	Collective Allostatic Load: A Study of Stress, Teamwork, and Resilience in the PICU Modeling Intra-operative staff scheduling decision making
	Rosenblatt, Kate, MD Assistant Professor, Anesthesiology and Critical Care Medicine Co-Director, Neurosurgical Anesthesia Fellowship Director of Outreach	Noninvasive monitoring of cerebral autoregulation in sepsis using cerebral oximetry.
	Santhanam, Lakshmi, PhD Associate Professor, Anesthesiology and Critical Care Medicine	Examining role of H2S producing enzymes in human microvascular function
	Scafidi, Susanna, MD Associate Professor, Anesthesiology and Critical Care Medicine	Clinical practice in management of seizures in pediatric abusive head trauma Retrospective review of clinical characteristics, management and outcomes of Pediatric patients with cerebral vasospasm
	Schiavi, Adam, MD, PhD, MS Associate Professor, Anesthesiology and Critical Care Medicine Neurology	Center for Immersive Simulation and Telemedicine (CISTEL) anesthesiology resident simulation training program
	Schramm, Jenny, MD Assistant Professor, Anesthesiology and Critical Care Medicine	Machine learning to identify risk factors for the development of necrotizing enterocolitis in children with congenital heart disease Collaborative Research with Pediatric Cardiac Intensive Care Society (CoRe-PCICS) I: Hyperoxia during CPB in Neonates
	Schwengel, Deborah, MD Associate Professor, Anesthesiology and Critical Care Medicine	mHealth Platform for the dissemination of vetted clinical medical knowledge to health professionals: A multi-center usability study The Development and Validation of a Procedural Checklist for a Simulation-Based Mastery Learning Curriculum for Ultrasound-Guided Interscalene Peripheral Nerve Blocks
	Segna, Kara, MD Assistant Professor, Anesthesiology and Critical Care Medicine	The impact of a multi-disciplinary pain medicine curriculum on attitudes surrounding pain and opioids
	Shah, Vishank, MD Assistant Professor, Anesthesiology and Critical Care Medicine Neurology	A Retrospective evaluation of the relationship between Intracranial pressure dynamics and Near-Infrared Spectroscopy (NIRS) signals in patients with aneurysmal subarachnoid hemorrhage admitted to the Neurocritical Care Unit
	Shechter, Ronen, MD Assistant Professor, Anesthesiology and Critical Care Medicine Pain Medicine	Perioperative Pain Program (PPP) role in minimizing opioid utilization, decreasing length of stay and improving clinical outcome measured using validated surveys in "opioid dependent" surgical patient population (ODSP).
	Sieber, Frederick, MD Professor, Anesthesiology and Critical Care Medicine	RESTORE (RESilience in TOtal knee REplacement)
	Shilkofski, Nicole, MD, MED Vice Chair of Education, Department of Pediatrics Residency Program Director, Pediatrics Associate Professor of Pediatrics	Design, Implementation and Evaluation of a Simulation-Based Peer to Peer Educational Intervention in Pediatric Resuscitation in Myanmar and Uganda Dissemination and Impact of Integrated Simulation Training in "Helping Babies Breathe" and "Helping Mothers Survive" Programs in the Philippines
	Sivanesan, Eellan, MD, FASA Director of Neuromodulation Associate Professor, Anesthesiology and Critical Care Medicine	Reuse of explanted spinal cord stimulators in rodents for the study of chronic pain Identification of Pain Related Genes and Neurochemical Changes in Dorsal Root Ganglion
	Smith Stierer, Tracey, MD Associate Professor, Anesthesiology and Critical Care Medicine Otolaryngology-Head and Neck Cancer	Multicenter Perioperative Outcomes Group (MPOG) and Anesthesiology Performance Improvement and Reporting Exchange (ASPIRE) Performance Site
	Steppan, Diana, MD, MPH Assistant Professor, Anesthesiology and Critical Care Medicine	Multicenter Retrospective Review of BAL in Pediatric HSCT patients
	Steppan, Jochen, MD, DESA, FAHA, FASA Director of Perioperative Medicine Associate Professor, Anesthesiology and Critical Care Medicine	Operating room procedures for high risk patients with pulmonary hypertension. LOXL2 in pulmonary hypertension
	Stevens, Robert, MD, MBA, FCCM Director, Division of Informatics, Integration, and Innovation, ACCM Precision Medicine Associate Director, Precision Medicine Center of Excellence Associate Professor, Anesthesiology and Critical Care Medicine	Physiological waveform analysis for clinical prediction in the intensive care unit Bridge2AI: A Patient-Focused Collaborative Hospital Repository Uniting Standards (CHoRUS) for Equitable AI
	Stockwell, David, MD, MBA Chief Medical Officer, Johns Hopkins Children's Center Professor, Anesthesiology and Critical Care Medicine	Disparities in Voluntary Event Reporting within an Academic Health System Epidemiology of Pediatric Intensive Care Patients using the Pediatric Health Information System Database
	Suarez, Jose, MD, FNCS, FANA, FAAN Professor and Chief, Neurosciences Critical Care Director, Precision Medicine Center of Excellence for Neurocritical Care Professor, Anesthesiology and Critical Care Medicine, Neurology, and Neurosurgery	Physiologic Data Capture and Analysis in the Neuroscience Critical Care Unit The Johns Hopkins Precision Medicine Center of Excellence in Neurocritical Care
	Suffredini, Giancarlo, MD Assistant Professor, Anesthesiology and Critical Care Medicine	Evaluating the relationship between liver stiffness as obtained by 2D-Shear Wave Elastography and illness severity in patients with COVID-19.
	Toy, Serkan, PhD, Med Assistant Professor, Anesthesiology and Critical Care Medicine	Using Electroencephalography to Measure Neurocognitive Engagement and Cognitive Load During Procedural and Clinical Decision-making Tasks
	Tran, Tina, MD Chief of Anesthesia at the Wilmer Eye Institute Assistant Professor, Anesthesiology and Critical Care Medicine	Improved Cable Management System for Anesthesia Monitoring Devices Used in Surgical and Critical Care Settings Developing a 4 Week Learner-Focused Anesthesia Clerkship Curriculum to Promote Medical Student Active Learning in the Clerkship Setting
	Vanderhoek, Samuel, MD Associate Professor, Anesthesiology and Critical Care Medicine	Patterns and Practices of Perioperative Insulin Pump Management in Children with Diabetes Understanding Provider Practices in Pediatric Ambulatory Anesthesia
	Vecchione, Tricia, MD Associate Professor, Anesthesiology and Critical Care Medicine	Trajectories of Pediatric Patients With Acute Compartment Syndrome or Limb Ischemia Associated With Peripheral Nerve Blocks
	Winters, Bradford, PhD, MD, FCCM Division Director, Adult Critical Care Medicine Co-Director, JHH Surgical ICUs, Bayview Medical Center and Burn ICUs, Armstrong Inst. For Patient Safety and Quality Professor, Anesthesiology and Critical Care Medicine Surgery	CUSP for Diagnostic Accuracy and Antibiotic Stewardship in Telemedicine
	Wolpaw, Jed, MD, M.Ed Professor Anesthesiology and Critical Care Medicine Residency Program Director	Examining the interplay between physical activity, sleep, work schedule, and burn-out in anesthesiology residents Unconscious Bias In Anesthesia Residency Applicant Letters of Recommendation
	XIE, Anping, PhD Associate Professor Anesthesiology and Critical Care Medicine	Evaluation of an Intervention for Improving Patient Engagement in Perioperative Pain Management Strategies for Improving Prescription Opioid Use in Perioperative Pain Management
	Ziai, Wendy, MD, MPH Assistant Professor Anesthesia and Critical Care Medicine Neurology and Neurosurgery	REpeated ASSEssment of SurvivorS in Intracerebral Hemorrhage Study Biomarker and Edema Attenuation in IntraCerebral Hemorrhage (BEACH) Phase 2a trial