What We Do

Chronic pain causes significant suffering, but treatment remains a significant unmet medical need. The long-standing scientific focus of our laboratory is to elucidate the spinal and peripheral mechanisms of pain to develop better strategies and novel targets for pain treatment. We have built a multidisciplinary team that incorporates expertise in the electrophysiology, behavioral pharmacology, in vivo calcium imaging, cell and molecular biology. Our laboratory is also a major component of the Pain Research Core and the Pain Neuromodulation Research Program at the Johns Hopkins University. We have a demonstrated record of productive research projects in areas that are of high relevance for patients suffering from chronic pain. Major areas of our research include: 1) Mechanistic study of neurostimulation for neuropathic pain treatment; 2) Discovering new targets for non-opioid treatment of chronic pain; 3) Examining new strategies to improve opioid analgesia; 4) Regenerative pain medicine for post-surgical pain, cancer pain and spinal cord injury pain conditions.

Yun Guan, MD, PhD
The Johns Hopkins University School of Medicine
Department of Anesthesiology and Critical Care Medicine
Department of Neurological Surgery
Director, Pain Research Core
Director, Pain Neuromodulation Research
720 Rutland Avenue, Ross 350-351
Baltimore, MD 21205