Grants Received

Sung-Min Cho, DO, MHS, is PI on three recently funded grants. The first grant is a BOOST grant from the Johns Hopkins ICTR for the AFERCOR study, in which he will investigate long-term neurological outcomes of ICU patients with COVID-19. The funds will cover Clinical Research Unit costs. The second grant is a Johns Hopkins-funded COVID-19 Bridge Grant with co-PI Glenn Whitman. The funds will support a postdoctoral fellow for ECMO research. The third grant, funded by Hyperfine, will support the SAFE MRI study. The purpose of this study is to investigate safety and feasibility of using portable MRI for ECMO patients.

Tina Doshi, MD, MHS, was awarded a 3-year Research Supplement to an existing NIH UH3 grant, “Sequenced-strategy for improving outcomes in people with Knee OsteoArthritis Pain (SKOAP)” trial, as part of the NIH Helping to End Addiction Long-term (HEAL) Initiative.  The project is jointly funded through NIAMS and NINDS and will investigate inflammatory profiles as biomarkers in chronic pain.

Tina Doshi, MD, MHS, is a Co-Investigator (site PI) of a 5-year, multi-site NIH R01 with the University of Maryland (PI: Luana Colloca, UMB) for “Neural Mechanisms of Immersive Virtual Reality in Chronic Pain.” The study is supported by the NCCIH and will investigate virtual reality use in patients with temporomandibular disorder.

Yun Guan, MD, PhD, and Srinivasa Raja, MD, are co-investigators on a UH3 phase of an NIH HEAL grant for development of a new drug for pain treatment. The title of the grant is Development of MRGPRX1 positive allosteric modulators as non-addictive therapies for neuropathic pain, and the PI is Takashi Tsukamoto of the Johns Hopkins Brain Science Institute. Funding will be $1,524,982 per year.

Accomplishments and Honors

Sung-Min Cho, DO, MHS, spoke at the European Society of Intensive Care Medicine webinar on “Management of Malignant MCA Stroke—What the Intensivist Needs to Know.”

An article written by Tina Doshi, MD, MHS, and Gerard Limerick, MD, titled “Utilizing CGRP Antagonists for Non-Migraine Indications,” was one of the “Most Read Articles” in Practical Pain Management.

Tina Doshi, MD, MHS, was invited to serve a 1-year term on an Expert Panel on Integrative and Mental Health for the Arthritis Foundation.

Anita Gupta, DO, MPP, PharmD, published an article in Forbes magazine titled “What We Can Do About the Opioid Crisis During the Pandemic.”

Sean Love, MD, Donald Herdt, MD, and Sean Berenholtz, MD, MHS, FCCM, published an article in the ASA Monitor (September 2021; 85:e2) titled Simplifying Hospital Communication Technology with vCards.

AudioDigest Anesthesiology published a lecture given by Jochen Steppan, MD, titled Pulmonary Hypertension. The recording was made in May of 2020 and was published on August 21, 2021 (volume 63, issue 31). It can be heard here.

Jochen Steppan, MD, FASA, was awarded the designation Fellow of the American Society of Anesthesiologists.

M-Irfan Suleman, MD, FAAP, FASA, was appointed to serve on the 2022 American Society of Anesthesiologists Educational Track Subcommittee on Pain Medicine.

Jed Wolpaw, MD, MEd, gave Grand Rounds at the Maine Medical Center Department of Anesthesiology on September 2^nd and at the University of Florida, Jacksonville, on September 8^th. The first talk was titled “Maximizing Clinical Training and Trainee Well-being,” and the second talk was “Reimagining Residency, What Should Training Look Like for Today’s Adult Learners?”

Articles Published

Basic and Translational Research

El Demerdash N, Chen MW, O’Brien CE, Adams S, Kulikowicz E, Martin LJ, Lee JK. Oleuropein activates neonatal neocortical proteasomes, but proteasome gene targeting by AAV9 is variable in a clinically relevant piglet model of brain hypoxia-ischemia and hypothermia. Cells. 2021; 10.

Flavahan NA. New mechanism-based approaches to treating and evaluating the vasculopathy of scleroderma. Curr Opin Rheumatol. 2021; in press.

Qureshi AY, Stevens RD. Mapping the unconscious brain: insights from advanced neuroimaging. J Clin Neurophysiol. 2021; in press.

Santhanam L, Liu G, Jandu S, Su W, Wodu BP, Savage W, Poe A, Liu X, Alexander LM, Cao X, Wan M. Skeleton-derived PDGF-BB mediates arterial stiffening. J Clin Invest. 2021; in press.

Sharma A, Sah N, Kannan S, Kannan RM. Targeted drug delivery for maternal and perinatal health: challenges and opportunities. Adv Drug Deliv Rev. 2021; 177:113950.

Stephens KE, Zhou W, Renfro Z, Ji Z, Ji H, Guan Y, Taverna SD. Global gene expression and chromatin accessibility of the peripheral nervous system in animal models of persistent pain. J Neuroinflammation. 2021; 18:185.

Clinical Research

Cho SM, Floden D, Wallace K, Hiivala N, Joseph S, Teuteberg J, Rogers JG, Pagani FD, Mokadam N, Tirschwell D, Li S, Starling RC, Mahr C, Uchino K. Long-term neurocognitive outcome in patients with continuous flow left ventricular assist device. JACC: Heart Fail. 2021; in press.

Cho SM, Mehaffey JH, Meyers SL, Cantor RS, Starling RC, Kirklin JK, Jacobs JP, Kern J, Uchino K, Yarboro LT. Cerebrovascular events in patients with centrifugal-flow left ventricular assist devices: propensity score-matched analysis from the intermacs registry. Circulation. 2021; 144:763-772.

Fan TH, Cho SM, Prayson RA, Hassett CE, Starling RC, Uchino K. Cerebral microvascular injury in patients with left ventricular assist device: a neuropathological study. Transl Stroke Res. 2021; in press.

Gusdon AM, Thompson CB, Quirk K, Mayasi YM, Avadhani R, Awad IA, Hanley DF, Ziai WC. CSF and serum inflammatory response and association with outcomes in spontaneous intracerebral hemorrhage with intraventricular extension: an analysis of the CLEAR-III Trial. J Neuroinflammation. 2021; 18:179.

Huth SF, Cho SM, Robba C, Highton D, Battaglini D, Bellapart J, Suen JY, Li Bassi G, Taccone FS, Arora RC, Whitman G, Fraser JF, Fanning JP. Neurological manifestations of coronavirus disease 2019: a comprehensive review and meta-analysis of the first 6 months of pandemic reporting. Front Neurol. 2021; 12:664599.

LaRosa JM, Kudchadkar SR. Rehabilitation utilization in the PICU: a complicated picture. Crit Care Med. 2021; 49:1582-1584.

Laskow T, Zhu J, Buta B, Oni J, Sieber F, Bandeen-Roche K, Walston J, Franklin PD, Varadhan R. Risk factors for non-resilient outcomes in older adults after total knee replacement in the FORCE-TJR cohort. J Gerontol A Biol Sci Med Sci. 2021; in press.

Machado R, Welch CL, Haimel M, Bleda M, Colglazier E, Coulson JD, Debeljak M, Ekstein J, Fineman JR, Golden WC, Griffin EL, Hadinnapola C, Harris MA, Hirsch Y, Hoover-Fong J, Nogee L, Romer LH, Vesel S, Graf S, Morrell N, Southgate L, Chung W. Biallelic variants of ATP13A3 cause dose-dependent childhood-onset pulmonary arterial hypertension characterised by extreme morbidity and mortality. J Med Genet. 2021; in press.

McSherry ML, Kudchadkar SR. Prognostic conversations in the PICU: are we even coming close? Pediatr Crit Care Med. 2021; 22:844-847.

Peeler A, Gleason KT, Ferrell B, Battista V, Klinedinst R, Cho SM, Davidson PM. Extracorporeal membrane oxygenation: opportunities for expanding nurses’ roles. AACN Adv Crit Care. 2021; 32:341-345.

Perry MA, Dawkins-Henry OS, Awojoodu RE, Blumenthal J, Asaro LA, Wypij D, Kudchadkar SR, Zuppa AF, Curley MAQ. Study protocol for a two-center test of a nurse-implemented chronotherapeutic restoring bundle in critically ill children: RESTORE Resilience (R²). Contemp Clin Trials Commun. 2021; 23:100840. Supported by the CRC.

Steppan J. Perioperative pulmonary hypertension pathway. CASA Bulletin of Anesthesiology. 2021; 8:45-50.

Turnbull AE, Ji H, Dinglas VD, Wu AW, Mendez-Tellez PA, Himmelfarb CD, Shanholtz CB, Hosey MM, Hopkins RO, Needham DM. Understanding patients’ perceived health after critical illness: analysis of two prospective, longitudinal studies of ARDS survivors. Chest. 2021; in press.

Van Boxem K, Cohen SP, Kuijk van SMJ, Hollmann MW, Zuidema X, Kallewaard JW, Benzon HT, Van Zundert J. Systematic review on epidural steroid injections: Quo vadis? Clin J Pain. 2021; in press.

Operations

Booth LD, Sick-Samuels AC, Milstone AM, Fackler JC, Gnazzo LK, Stockwell DC. Culture ordering for patients with new-onset fever: a survey of pediatric intensive care unit clinician practices. Pediatr Qual Saf. 2021; 6:e463.

Wong T, Zhang EJ, Elhajj AJ, Rizzo DM, Sexton KA, Pandit JJ, Tsai MH. The power law in operating room management. J Med Syst. 2021; 45:92.

Physiocloud

Bose SN, Greenstein JL, Fackler JC, Sarma SV, Winslow RL, Bembea MM. Early prediction of multiple organ dysfunction in the pediatric intensive care unit. Front Pediatr. 2021; 9:711104.

Quality Improvement

Aboumatar H, Thompson C, Garcia-Morales E, Gurses AP, Naqibuddin M, Saunders J, Kim SW, R AW. Perspective on reducing errors in research. Contemp Clin Trials Commun. 2021; 23:100838.