Grants Received

Nauder Faraday, MD, received 3 years of funding from the National Science Foundation for his project titled “PFI-RP: Clinical Decision Support Tool to Identify Patients Diagnosed with Heart Failure Who Are at High Risk of 30-day Hospital Readmission.”

Carlie Myers, MD, MS, was funded by the NIH/NHLBI for her project titled “ECMO Utilization in Maryland.” This grant, which is supported by the Loan Repayment Program, will pay $100,000 over 2 years towards Carlie’s student loan repayment. Carlie’s mentor on the project is Mela Bembea, MD, PhD.

Eellan Sivanesan, MD, received a 2-year NIH LRP award for his project titled “Spinal Cord Stimulation for Enhanced Chemotherapeutic Efficacy and the Attenuation of Chemotherapy-induced Peripheral Neuropathy.” Funding for this award is through the National Cancer Institute.

 

Accomplishments and Honors

Matt Austin, PhD, of the Armstrong Institute was promoted to Associate Professor.

Nick Dalesio, MD, MPH, was promoted to Associate Professor.

Anita Gupta, DO, MPP, PharmD, was appointed as a Harvard Business School Ambassador and an elected Board of Governor of Princeton University, A4P. She was also appointed to the U.S. Department of Defense as a Scientific Advisor.

Sujatha Kannan, MD, and her team were one of three groups to receive the first-ever ICTR Team Science Award. Her team, known as the “Targeted Nanomedicine Team” is working to create pharmacological interventions for perinatal brain injury by conjugating small molecule drugs to hydroxyl-terminated poly(amidoamine) dendrimers to improve brain penetration and bioavailability. Besides Dr. Kannan, the team includes Dr. Nirnath Sah, Jinhuan Liu, Amanda Fowler, Alicia Chime, and Dr. Elizabeth Khoury from ACCM; Dr. Kannan Rangaramanujam, Dr. Anjali Sharma, and Dr. Wathsala Liyanage from the Department of Ophthalmology; Dr. Barbara Slusher from Neurology/Johns Hopkins Drug Discovery; Dr. Frances Northington, Debbie Flock, and Victoria Turnbill from the Department of Pediatrics; Tony Wu from Johns Hopkins WSE: Chemical and Biomolecular Engineering; Dr. Rana Rais from the Department of Neurology, and Dr. Jesse Alt from Johns Hopkins Drug Discovery.

Darren Klugman, MD, was promoted to Associate Professor.

Aliaksei Pustavoitau, MD, was promoted to Associate Professor.

Deborah Schwengel, MD, was appointed Editor-in-Chief of the Patient Safety Editorial Board for the American Society of Anesthesiologists (ASA). Her term as chief will begin in October 2021 as the outgoing chief, Dr. Jane Easdown of Vanderbilt University, hands over the reins.

Eellan Sivanesan, MD, recently gave grand rounds at the University of Florida College of Medicine-Jacksonville on “Anesthetic Management of Implanted Pain Devices” and spoke for the Children’s Tumor Foundation and at the Neural Interfaces 2021 NANS-NIC Meeting.

Jochen Steppan, MD, was invited to serve a 2-year term as an adjunct member of the Committee on Research for the ASA. He was also appointed to a 1-year term as a member of the ASA Educational Track Subcommittee on Cardiac Anesthesia. Both appointments will begin in October 2021.

M-Irfan Suleman, MD, FAAP, FASA, was appointed to serve on the 2022 ASA Educational Track Subcommittee on Regional Anesthesia and Acute Pain.

M-Irfan Suleman, MD, FAAP, FASA, gave an invited talk titled “Multidisciplinary Pediatric Chronic Pain Management” for Aga Khan University, Karachi, Pakistan, on August 6^th.

Kelly Vasquenza, CRNP, a pediatric acute pain nurse practitioner in ACCM, was chosen by the Johns Hopkins Hospital Advanced Practice Advisory Council for the Advanced Practice Appreciation Award. This award recognizes individuals for their clinical excellence and their embodiment of The Johns Hopkins Hospital.

Tricia Vecchione, MD, MPH, gave a grand rounds presentation at the University of Mississippi Medical Center titled “The Role of Pediatric Regional Anesthesia” on July 21^st.

 

Articles Published

Basic and Translational Research

Elassal A, Steppan J, Charania S, Santhanam L, Singh I, Heerdt PM. Pressure-based estimation of right ventricular ejection fraction: Validation as a clinically relevant target for drug development in a rodent model of pulmonary hypertension. J Pharmacol Toxicol Methods. 2021; 112:107102.

Hilz EN, Lewis SM, Olshavsky ME, Khoury ES, Gore AC, Monfils MH, Lee HJ. Sex differences in conditioned orienting and the role of estradiol in addiction-related behaviors. Behav Neurosci. 2021; in press.

Kumar A, Narayan RK, Kulandhasamy M, Prasoon P, Kumari C, Kumar S, Pareek V, Sesham K, Shekhawat PS, Kant K, Kumar S. COVID-19 pandemic: insights into molecular mechanisms leading to sex-based differences in patient outcomes. Expert Rev Mol Med. 2021; 23:e7.

Schwartz SM, Barpujari A, Finnerup NB, Raja SN. Pharmacologic therapies for neuropathic pain: an assessment of reporting biases in randomized controlled trials. Pain. 2021; in press.

Sharma R, Liaw K, Sharma A, Jimenez A, Chang M, Salazar S, Amlani I, Kannan S, Kannan RM. Glycosylation of PAMAM dendrimers significantly improves tumor macrophage targeting and specificity in glioblastoma. J Control Release. 2021; 337:179-192.

Sharma R, Porterfield JE, An HT, Jimenez AS, Lee S, Kannan S, Sharma A, Kannan RM. Rationally designed galactose dendrimer for hepatocyte-specific targeting and intracellular drug delivery for the treatment of liver disorders. Biomacromolecules. 2021; 22:3574-3589.

Tuday E, Nakano M, Akiyoshi K, Fu X, Shah AP, Yamaguchi A, Steenbergen C, Santhanam L, An SS, Berkowitz D, Baraban JM, Das S. Degradation of premature-miR-181b by the translin/trax RNase increases vascular smooth muscle cell stiffness. Hypertension. 2021; in press.

Wang H, Chen J, Jandu S, Melucci S, Savage W, Nandakumar K, Kang SK, Barreto-Ortiz S, Poe A, Rastogi S, Bauer M, Steppan J, Santhanam L. Probing tissue transglutaminase mediated vascular smooth muscle cell aging using a novel transamidation-deficient Tgm2-C277S mouse model. Cell Death Discov. 2021; 7:197.

Wang H, Pai S, Ishiyama S, Guo X, Gao WD, Santhanam L, Gabrielson K, Njoku DB. Mitochondrial-triggered immune responses mechanistically connect drug-induced steatohepatitis and cardiomyopathy associated with nonalcoholic steatohepatitis. Cell Mol Immunol. 2021; 18:2078-2080.

Xue P, Wang S, Lyu X, Wan M, Li X, Ma L, Ford NC, Li Y, Guan Y, Ding W, Cao X. PGE2/EP4 skeleton interoception activity reduces vertebral endplate porosity and spinal pain with low-dose celecoxib. Bone Res. 2021; 9:36.

 

Clinical Research

Bronshteyn YS, Anderson TA, Badakhsh O, Boublik J, Brady MBW, Charnin JE, Coker BJ, Deriy LB, Hardman HD, Haskins SC, Hollon M, Hsia HJ, Neelankavil JP, Panzer OPF, Perlas A, Ramsingh D, Sharma A, Shore-Lesserson LJ, Zimmerman JM. Diagnostic point-of-care ultrasound: Recommendations from an expert panel. J Cardiothorac Vasc Anesth. 2021; in press.

Carhuapoma LR, Kapadia A, Glick HA, Hanley DF. What is the price of the potential for a meaningful recovery following intracerebral hemorrhage? J Stroke Cerebrovasc Dis. 2021; in press:106017.

Cho SM, Mehaffey JH, Myers SL, Cantor RS, Starling RC, Kirklin JK, Jacobs JP, Kern J, Uchino K, Yarboro L. Cerebrovascular events in patients with centrifugal-flow left ventricular assist devices: a propensity score matched analysis from the intermacs registry. Circulation. 2021; in press.

Cho SM, Premraj L, Fanning J, Huth S, Barnett A, Whitman G, Arora RC, Battaglini D, Porto DB, Choi H, Suen J, Bassi GL, Fraser JF, Robba C, Griffee M. Ischemic and hemorrhagic stroke among critically ill patients with coronavirus disease 2019: an international multicenter Coronavirus Disease 2019 Critical Care Consortium Study. Crit Care Med. 2021.

Cohen SP. Toast, jam, and radiofrequency. Pain Med. 2021; in press.

Cohen SP, Greuber E, Vought K, Lissin D. Safety of epidural steroid injections for lumbosacral radicular pain: unmet medical need. Clin J Pain. 2021; in press.

Cox CJ, Wilkinson MM, Erdek MA. Successful spinal cord stimulation for chronic pancreatitis and post-laminectomy pain. Pain Manag. 2021; in press.

Dalesio NM, Burgunder L, Diaz-Rodriguez NM, Jones SI, Duval-Arnould J, Lester LC, Tunkel DE, Kudchadkar SR. Factors associated with pediatric emergency airway management by the difficult airway response team. Cureus. 2021; 13:e16118.

Geocadin RG, Cho SM. Is neuromonitoring the key to better outcome in postcardiac arrest syndrome? Crit Care Med. 2021; 49:1369-1371.

Giuliano K, Bigelow BF, Etchill EW, Velez AK, Ong CS, Choi CW, Bush E, Cho SM, Whitman GJR. Extracorporeal membrane oxygenation complications in heparin- and bivalirudin-treated patients. Crit Care Explor. 2021; 3:e0485.

Gracie TJ, Caufield-Noll C, Wang NY, Sieber FE. The association of preoperative frailty and postoperative delirium: a meta-analysis. Anesth Analg. 2021; 133:314-323.

Greenberg JK, Ahluwalia R, Hill M, Johnson G, Hale AT, Belal A, Baygani S, Olsen MA, Foraker RE, Carpenter CR, Yan Y, Ackerman L, Noje C, Jackson E, Burns E, Sayama CM, Selden NR, Vachhrajani S, Shannon CN, Kuppermann N, Limbrick DD, Jr. Development and external validation of the KIIDS-TBI tool for managing children with mild traumatic brain injury and intracranial injuries. Acad Emerg Med. 2021; in press.

Hoops K. Opening the door to a discussion on gun safety. JAMA Health Forum. 2021; 2:e211586.

Huang M, Gedansky A, Hassett CE, Price C, Fan TH, Stephens RS, Nyquist P, Uchino K, Cho SM. Pathophysiology of brain injury and neurological outcome in acute respiratory distress syndrome: a scoping review of preclinical to clinical studies. Neurocrit Care. 2021; in press:1-10.

Hunsberger JB, Rathee V, Smith TJ. Use of scrambler therapy in the treatment of amyloidosis neuropathic pain. J Palliat Med. 2021; in press.

Ijsselstijn H, Schiller RM, Holder C, Shappley RKH, Wray J, Hoskote A, Raman L, MacLaren G, Peek G, Bembea MM, Guerguerian AM. Extracorporeal Life Support Organization (ELSO) guidelines for follow-up after neonatal and pediatric extracorporeal membrane oxygenation. ASAIO J. 2021; in press.

Ilfeld BM, Khatibi B, Maheshwari K, Madison SJ, Ali Sakr Esa W, Mariano ER, Kent ML, Hanling S, Sessler DI, Eisenach JC, Cohen SP, Mascha EJ, Yang D, Padwal JA, Turan A. Immediate effects of a continuous peripheral nerve block on postamputation phantom and residual limb pain: secondary outcomes from a multicenter randomized controlled clinical trial. Anesth Analg. 2021; in press.

Ilfeld BM, Plunkett A, Vijjeswarapu AM, Hackworth R, Dhanjal S, Turan A, Cohen SP, Eisenach JC, Griffith S, Hanling S, Sessler DI, Mascha EJ, Han Y, Boggs JW, Wongsarnpigoon A, Gelfand H. Percutaneous neuromodulation of the brachial plexus and sciatic nerve for the treatment of acute pain following surgery: Secondary outcomes from a multicenter, randomized, controlled pilot study. Neuromodulation. 2021; in press.

Ilfeld BM, Plunkett A, Vijjeswarapu AM, Hackworth R, Dhanjal S, Turan A, Cohen SP, Eisenach JC, Griffith S, Hanling S, Sessler DI, Mascha EJ, Yang D, Boggs JW, Wongsarnpigoon A, Gelfand H. Percutaneous peripheral nerve stimulation (neuromodulation) for postoperative pain: A randomized, sham-controlled pilot study. Anesthesiology. 2021; 135:95-110.

Ista E, Redivo J, Kananur P, Choong K, Colleti J, Jr., Needham DM, Awojoodu R, Kudchadkar SR. Assessing pain, both spontaneous awakening and breathing trials, choice of sedation, delirium monitoring/management, early exercise/mobility, and family engagement/empowerment bundle practices for critically ill children: an international survey of 161 PICUs in 18 countries. Crit Care Med. 2021; in press.

Kuza CM, To J, Chang A, Mert M, Yau A, Singh M, Choi KJ, Huang S, Wier J, Inaba K, Hirji SA, Spencer D, Albertson S, Grigorian A, Nahmias JT. A retrospective data analysis on the induction medications used in trauma rapid sequence intubations and their effects on outcomes. Eur J Trauma Emerg Surg. 2021; in press:1-12.

Lewis C, Levine A, Balmert LC, Chen L, Sherwani SS, Nemeth AJ, Grafman J, Gottesman R, Brown CHt, Hogue CW. Neurocognitive, quality of life, and behavioral outcomes for patients with covert stroke after cardiac surgery: exploratory analysis of data from a prospectively randomized trial. Anesth Analg. 2021; in press.

Nguyen MC, Lee EJ, Avery RK, Dioverti-Prono MV, Shoham S, Tobian AAR, Bloch EM, Gurakar A, Rizkalla NA, Cameron AM, King EA, Ottmann S, Garonzik-Wang JM, Wesson RN, Philosophe B. Transplant of SARS-CoV-2-infected living donor liver: case report. Transplant Direct. 2021; 7:e721.

Penchev R, Scheuring RA, Soto AT, Miletich DM, Kerstman E, Cohen SP. Back pain in outer space. Anesthesiology. 2021; in press.

Raja SN, Buvanendran A, Marcondes L. Complex regional pain syndrome: a comprehensive qualitative research study on unmet needs in the “patient journey”. J Pain Res. 2021; 14:2391-2401.

Sindhi V, Lim CG, Khan A, Pino C, Cohen SP. Dural puncture during lumbar epidural access in the setting of degenerative spondylolisthesis: case series and risk mitigation strategies. Reg Anesth Pain Med. 2021; in press.

 

Education

Ahluwalia T, Toy S, Gutierrez C, Boggs K, Douglass K. Feasible and effective use of a simulation-based curriculum for post-graduate emergency medicine trainees in India to improve learner self-efficacy, knowledge, and skills. Int J Emerg Med. 2021; 14:42.

Good RJ, Zurca AD, Turner DA, Bjorklund AR, Boyer DL, Krennerich EC, Petrillo T, Rozenfeld RA, Sasser WC, Schuette J, Tcharmtchi MH, Watson CM, Czaja AS. Transport medical control education for pediatric critical care fellows: a national needs assessment study. Pediatr Crit Care Med. 2021; in press.

 

Physiocloud

Afshar AS, Li Y, Chen Z, Chen Y, Lee JH, Irani D, Crank A, Singh D, Kanter M, Faraday N, Kharrazi H. An exploratory data quality analysis of time series physiologic signals using a large-scale intensive care unit database. JAMIA Open. 2021; 4:ooab057.