ACCM Achievements August 2025 – Johns Hopkins Anesthesiology and Critical Care Medicine

Tsion Shiferaw, a Baltimore City High School student, presents her work during the Johns Hopkins Internship in Brain Sciences Program’s final research presentations, August 15, 2025. Tsion spent 8 weeks this summer interning, and contributing to research in Susanne Muehlschlegel’s Lab.

Reminder: ACCM Applause is a place for us to celebrate our colleagues for the outstanding work they do every day. Do you know someone who deserves recognition? Click here to give them an Applause!

Marie DeFrancesco-Malviya
“Marie is just as amazing mentor and preceptor. She inspired and motivated me to fulfill my dream to be a CRNA someday. Shadowing with her is one of the best experiences I have ever had in terms of my learning curvature. She is very knowledgeable, and she explains everything where a student can understand it easily. Being with her during the cases made me realize that being a CRNA is the job that I wanted to do that I will love the most.” – Ian Rafael Marpha

Marie DeFrancesco-Malviya
“Marie is a great CRNA giving us a thorough patient report. Any questions regarding our patients she’s ready to help us. A supportive , compassionate and loving co worker . We love her . Yesterday, the PACU was extremely busy and we didn’t have time for breaks. Marie gave her entire cake she had baked for her staff and we were able to grab a bite to stay strong. She’s an asset to this organization!” – Asteria Montales

GRANTS RECEIVED

Lee Goeddel, MD, MPH (PI), was awarded an NIH K-23 Patient Oriented Mentored Career Development Award funded by the National Heart, Lung, and Blood Institute. His project is titled “Cardiac Output and Renal Perfusion Alterations in the Development of Acute Kidney Injury in Cardiac Surgery”.

Qin Zheng, MD, PHD (PI), was awarded and NIH R01 funded by the National Cancer Institute. Her project is titled “Determining the function of medium to large diameter sensory neurons in paclitaxel induced pain via large-scale in vivo DRG imaging”.

ACCOMPLISHMENTS AND HONORS

Nadia Hensley, MD, gave an invited talk to the Charite Heart Center in Berlin, Germany on Tuesday Aug 19^th entitled, “The High Hanging Fruit- Preoperative Anemia Management in Cardiac Surgery Patients”.

Promotions and Appointments

Ozan Akca, MD, FCCM, has been appointed as the new Director of Adult Clinical Research in the Department of Anesthesiology & Critical Care Medicine.

Mark Romig, MD, has been named as Director of Critical Care for the new Johns Hopkins Special Pathogens Center. https://www.hopkinsmedicine.org/special-pathogens-center

Kara Segna, MD, has been promoted to Associate Professor of Anesthesiology & Critical Care Medicine and has been appointed to the Abstract Committee for ASA under Regional Anesthesia and Acute Pain.

Eellan Sivanesan, MD, was appointed to the American Society of Anesthesiologists (ASA) Committee on Research and elected as a full member of the Association of University Anesthesiologists (AUA).

Jochen Steppan, MD, DESA, FAHA, has been appointed a three-year Member term of ASA’s 2026 Committee on Research and also has been appointed to the ASA’s 2026 Educational Track Subcommittee on Cardiac Anesthesia.

Heather Velaetis, MHS, PA-C, has been appointed as the inaugural Advanced Practice Provider (APP) Liaison for Critical Care for the Johns Hopkins Health System.

Scott Watkins, MD, has been promoted to Associate Professor of Anesthesiology & Critical Care Medicine.

ARTICLES PUBLISHED

Artificial Intelligence, Precision Medicine, and Machine Learning

Friedman RK, Heath AS, Huffman JE, Baker JT, Hasbani NR, Gagliano Taliun SA, Chen MH, Howard TE, Lewis JP, Pankratz N, Patil S, Reiner AP, Thibord F, Yanek LR, Yao J, Chen HH, Curran JE, Faraday N, Guo X, Wheeler MM, Ryan KA, Zhou X, Cho K, Almasy L, Auer PL, Becker LC, Wilson PWF, Boerwinkle E, O’Connell JR, Rich SS, Samuels DC; National Heart, Lung and Blood Institute (NHLBI) Trans-Omics for Precision Medicine (TOPMed) Consortium; TOPMed Hematology & Hemostasis Working Group; VA Million Veteran Program; Blangero J, Fornage M, Kooperberg C, Mathias RA, Mitchell BD, Rotter JI, Johnson AD, Smith NL, Coban-Akdemir ZH, Below JE, Morrison AC, Johnsen JM, de Vries PS. Genetic study of von Willebrand factor antigen levels ≤ 50 IU/dL identifies variants associated with increased risk of von Willebrand disease and bleeding. J Thromb Haemost. 2025 Aug;23(8):2410-2421. doi: 10.1016/j.jtha.2025.04.029. Epub 2025 May 12. PMID: 40368142.

Lagares A, Depreitere B, Marklund N, Castano Leon AM, Posti JP, Younsi A, Klein S; EANS Neurotrauma and Critical Care Section and expert panel members. Consensus on the management of traumatic brain injury in older adults: Results from a Delphi study. Brain Spine. 2025 Jul 11;5:104319. doi: 10.1016/j.bas.2025.104319. PMID: 40718845; PMCID: PMC12296501.

Leng A, Cho SM. Clarifying Interpretability and Real-World Application of Machine Learning-Based Prognostic Models in Extracorporeal Membrane Oxygenation. ASAIO J. 2025 Jul 31. doi: 10.1097/MAT.0000000000002525. Epub ahead of print. PMID: 40742205.Rastall DPW, Rehman M. Why Clinical Trials Will Fail to Ensure Safe AI. J Med Syst. 2025 Jul 17;49(1):98. doi: 10.1007/s10916-025-02231-x. PMID: 40670886.

Winter MC, Zhou AX, Laksana E, Aczon MD, Ledbetter DR, Avesar M, Burkiewicz K, Chandnani HK, Fainberg N, Hsu S, McCrory MC, Morrow KR, Noguchi A, O’Brien CE, Ojha A, Pringle C, Ross PA, Shah J, Shah S, Shpaner L, Siegel LB, Tripathi S, Wetzel RC; Pediatric Data Science and Analytics (PEDAL) subgroup of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Death One Hour After Terminal Extubation in Children: Validation of a Machine Learning Model to Predict Cardiac Death After Withdrawal of Life-Sustaining Treatment in a Multicenter Cohort, 2009-2021. Pediatr Crit Care Med. 2025 Aug 1;26(8):e997-e1008. doi: 10.1097/PCC.0000000000003772. Epub 2025 Jun 25. PMID: 40558604.

Basic and Translational Research

Ai Z, Li H, Xu S, Cai C, Wang X, Guan Y, Guo R, Wang Y. Overexpression of TAFA4 in the dorsal root ganglion ameliorates neuropathic pain in male rats through promoting macrophage M2-Skewing. Neurochem Int. 2025 Jul;187:105993. doi: 10.1016/j.neuint.2025.105993. Epub 2025 May 15. PMID: 40381955.

Bakare AO, Stephens K, Sanchez KR, Liu V, Zheng L, Goel V, Guan Y, Sivanesan E. Spinal cord stimulation attenuates paclitaxel-induced gait impairment and mechanical hypersensitivity via peripheral neuroprotective mechanisms in tumor-bearing rats. Reg Anesth Pain Med. 2025 Aug 5;50(8):675-684. doi: 10.1136/rapm-2024-105433. PMID: 38844412; PMCID: PMC11645439.

Cao M, Contreras-Rojas CS, Wang Q, Ahmed YB, Briscoe J, Pardo CA, Rando H, Kang JK, Whitman G, Keller S, Porras T, Cho SM. Exploring the Association Between Early PaCO₂ Correction Speed and Cerebrovascular Autoregulation in a Porcine Model of Extracorporeal Resuscitation. Transl Stroke Res. 2025 Aug 12. doi: 10.1007/s12975-025-01376-8. Epub ahead of print. PMID: 40794248.

Gok O, Sharma A, Kambhampati SP, Smith Khoury E, Kannan S, Kannan RM. Sustained and Step-Wise Drug Release by a Novel Double Responsive Dendrimer-N-Acetylcysteine Conjugate. Biomacromolecules. 2025 Jul 14;26(7):4274-4285. doi: 10.1021/acs.biomac.5c00283. Epub 2025 Jul 3. PMID: 40605647.

Guan AY, Chen Y, Tseng SC, Lin Q. CD44 signaling in skin wound healing and regeneration. J Transl Med. 2025 Aug 7;23(1):880. doi: 10.1186/s12967-025-06913-5. PMID: 40775777; PMCID: PMC12329881.

Jiang B, Graham E, Unberath M, Taylor RH, Koehler RC, Kang J, Boctor EM. Automatic photoacoustic monitoring of perinatal brain hypoxia with superior sagittal sinus detection. J Biomed Opt. 2025 Jul;30(7):076004. doi: 10.1117/1.JBO.30.7.076004. Epub 2025 Jul 11. PMID: 40655941; PMCID: PMC12245645.

Kothari R, Abdulrahim MW, Oh HJ, Capuzzi DH, Kilgore CB, Nair SK, Zhang Y, Limjunyawong N, Saini SS, Kim JE, Caplan JM, Gonzalez FL, Jackson CM, Bettegowda C, Huang J, Ganesh BP, Tan C, Koehler RC, Tamargo RJ, McCullough LD, Xu R, Dong X. A mast cell receptor mediates post-stroke brain inflammation via a dural-brain axis. Cell. 2025 Jul 24:S0092-8674(25)00747-0. doi: 10.1016/j.cell.2025.06.045. Epub ahead of print. PMID: 40712576; PMCID: PMC12313293.

Nyhan SM, Gadkari M, Brady T, Martinez Yus M, Choi R, Bauer M, Vithani S, Walpole J, Hays AG, Aziz H, Kilic A, Robich M, Gammie JS, Santhanam L, Steppan J. Preoperative serum LOXL2 levels are elevated in patients with pulmonary hypertension undergoing mitral valve surgery in a prospective observational cohort study. J Appl Physiol (1985). 2025 Aug 1;139(2):325-333. doi: 10.1152/japplphysiol.00287.2025. Epub 2025 Jul 10. PMID: 40637430; PMCID: PMC12320476.

Purohit MP, Yu BJ, Roy KS, Xiang Y, Ewbank SN, Azadian MM, Hart AR, Muwanga GPB, Martinez PJ, Wang JB, Taoube AK, Markarian E, Macedo N, Kwan AK, Lopez DG, Airan RD. Acoustically activatable liposomes as a translational nanotechnology for site-targeted drug delivery and noninvasive neuromodulation. Nat Nanotechnol. 2025 Aug 18. doi: 10.1038/s41565-025-01990-5. Epub ahead of print. PMID: 40826187.

Ruiz-Gonzalez CE, Nino-Meza OJ, Singh M, Masias-Leon Y, Kronenberg A, Shambles M, Chen X, Tucker EW, Lodge MA, Carroll LS, Cooke KR, Kates OS, Shoham S, Zhang SX, Jain SK. ¹⁸F-Fluorodeoxysorbitol PET for noninvasive detection of invasive mold infections: preclinical and first-in-human studies. Nat Commun. 2025 Jul 10;16(1):6395. doi: 10.1038/s41467-025-61700-6. PMID: 40640182; PMCID: PMC12246407.

Scafidi S, Xu S, Jernberg JN, Chu T, Fiskum G, McKenna MC. Longitudinal Brain Structural, Neurochemical, and Behavioral Changes Following Traumatic Brain Injury in Immature Rat Brain with ALCAR Treatment. Neurochem Res. 2025 Jul 30;50(4):256. doi: 10.1007/s11064-025-04494-9. PMID: 40736608; PMCID: PMC12310762.

Song Z, Wang X, Zeng J, Ren F, Wang Y, Li M, Lin Q, Li W, Liao X, Wang D. DHA and EPA exacerbate hypoxia-induced ferroptosis in gastric and small intestinal mucosa by disrupting the balance between SLC7A11 upregulation and PUFA-PL accumulation. J Lipid Res. 2025 Aug 12:100876. doi: 10.1016/j.jlr.2025.100876. Epub ahead of print. PMID: 40812725.

Yarnoff KM, Daccarett-Bojanini WN, Villabona-Rueda AF, Sollmann M, D’Alessio FR, Dodd-O JM. Hypomethylating therapy mitigates acute allograft rejection in a murine lung transplant model. Front Transplant. 2025 Jun 23;4:1612523. doi: 10.3389/frtra.2025.1612523. PMID: 40626170; PMCID: PMC12230056.

Clinical Research

Banik RK, Ko JS, Jiminez F, Horn DB, Sivanesan E, Park M, Cohen SP. Lost in conversion: navigating the challenges of converting intrathecal opioids to oral equivalents-a case report and literature review. Reg Anesth Pain Med. 2025 Jul 3:rapm-2025-106550. doi: 10.1136/rapm-2025-106550. Epub ahead of print. PMID: 40610220.

Bradshaw A, Bradshaw JC, Suffredini G, Hoover-Fong J, Gammie JS. Mitral Valve Repair in a Patient With Achondroplasia. JACC Case Rep. 2025 Aug 6;30(22):104654. doi: 10.1016/j.jaccas.2025.104654. PMID: 40780798.

Catchpole KR, Neyens DM, Abernathy JH 3rd, Biro J. Rethinking Anesthesia Medication “Errors”: The OR-SMART Patient Safety Learning Laboratory. J Patient Saf. 2025 Jul 7. doi: 10.1097/PTS.0000000000001384. Epub ahead of print. PMID: 40622243.

Cohen PD, Schultz BRE, Schuette J, Kudchadkar SR. N-Acetylcysteine and Hemodialysis in Severe Acetaminophen Toxicity in a 15-Year-Old Adolescent: A Case Report. Am J Case Rep. 2025 Aug 12;26:e948715. doi: 10.12659/AJCR.948715. PMID: 40794548; PMCID: PMC12357520.

Daza JF, Hamad DM, Urner M, Liu K, Wahlster S, Robba C, Stevens RD, McCredie VA, Cinotti R, Taran S; ENIO Study Group; PROtective VENTilation Network; European Society of Intensive Care Medicine; Colegio Mexicano de Medicina Critica; AtlanRéa Group; Société Française d’Anesthésie-Réanimation–SFAR Research Network. Low-Tidal-Volume Ventilation and Mortality in Patients With Acute Brain Injury: A Secondary Analysis of an International Observational Study. Chest. 2025 Jul 8:S0012-3692(25)00829-3. doi: 10.1016/j.chest.2025.06.042. Epub ahead of print. PMID: 40639639.

Delaney K, Roberts AR, Morrison JM, Leiding JW, Sochet AA. Systemic Corticosteroids for Acute Viral Bronchiolitis: A Retrospective Multicenter Cohort Study. Hosp Pediatr. 2025 Jul 1;15(7):590-597. doi: 10.1542/hpeds.2024-008221. PMID: 40527516.Bottom of Form

DeMayo KM, Havlicek EE, Palumbo J, Soto-Campos G, Betensky M, Goldenberg NA, Sochet AA. Diabetic Ketoacidosis and Venous Thromboembolism: A North American Virtual Pediatric Systems Registry Study, 2014-2023. Pediatr Crit Care Med. 2025 Jul 1;26(7):e924-e934. doi: 10.1097/PCC.0000000000003769. Epub 2025 May 29. PMID: 40439528.

Desai SA, Burke HW, Adaralegbe AO, Sweet JA, Hayek SM, Staudt MD. High Cervical Intrathecal Targeted Drug Delivery for Refractory Neuropathic Craniofacial Pain. Neuromodulation. 2025 Jun 28:S1094-7159(25)00224-7. doi: 10.1016/j.neurom.2025.05.007. Epub ahead of print. PMID: 40580170.

Doane K, Guffey D, Loftis LL, Nguyen TC, Musick MA, Ruth A, Coleman RD, Teruya J, Allen C, Bembea MM, Boville B, Furlong-Dillard J, Kaipa S, Leimanis M, Malone MP, Rasmussen LK, Said A, Steiner ME, Tzanetos DT, Viamonte H, Wallenkamp L, Saini A. Short-term neurologic outcomes in pediatric extracorporeal membrane oxygenation are proportional to bleeding severity graded by a novel bleeding scale. Perfusion. 2025 Jul;40(5):1267-1276. doi: 10.1177/02676591241293673. Epub 2024 Oct 18. PMID: 39425501; PMCID: PMC12202819.

Doré KJ, Kelly CM, Cornell TT, Rasmussen LK, Burk S, Loftis LL, Allen C, Bembea MM, Boville BM, Furlong-Dillard J, Kaipa S, Norton B, Viamonte H, Wallenkamp L, Said A, Steiner ME, Malone MP, Kline A, Tawfik D. Temporal trends and risk factors for bleeding and thrombosis in pediatric ECMO: A multicenter cohort study. Perfusion. 2025 Jul 31:2676591251365417. doi: 10.1177/02676591251365417. Epub ahead of print. PMID: 40741691.

Farrokh S, Nalleballe K, Onteddu S, Suarez JI, Bösel J, Shah VA. Bleeding Risk With Combining Antiplatelets and Anticoagulants for Secondary Stroke Prevention: A Propensity Score-Matched Analysis. J Am Heart Assoc. 2025 Aug 19;14(16):e042767. doi: 10.1161/JAHA.125.042767. Epub 2025 Aug 20. PMID: 40831308.

Feng SN, Laws LH, Diaz-Cruz C, Cinotti R, Schultz MJ, Asehnoune K, Stevens RD, Robba C, Cho SM; ENIO collaborators. Sedation Practices in Mechanically Ventilated Neurocritical Care Patients from 19 Countries: An International Cohort Study. Neurocrit Care. 2025 Aug;43(1):232-242. doi: 10.1007/s12028-024-02200-1. Epub 2025 Jan 7. PMID: 39776348.

Hsu YJ, Speed TJ, Prinzbach A, Sutton O, McDonald EM, Khasawneh A, Kim S, Samba I, Shechter R, Hanna MN, Marsteller JA, Xie A. Development and Early Validation of A Survey Instrument for Measuring Patient Engagement in Pain Management. Am J Med Qual. 2025 Jul-Aug 01;40(4):165-172. doi: 10.1097/JMQ.0000000000000236. Epub 2025 Mar 17. PMID: 40091179.

Imai T, Morais AL, Jin X, Qin T, Lamb J, Nagarkatti KA, Chen MH, Boisserand LSB, Patel RB, Kumskova M, Chauhan A, Dhandapani KM, Khan MB, Kamat PK, Shi Y, Cao S, Sanganahalli BG, Mandeville JB, Lyden PD, Hess DC, Leira EC, Chauhan AK, Aronowski J, McCullough LD, Koehler RC, Sansing LH, Diniz MA, Ayata C; SPAN Investigators. Multicenter SPAN Trial of Fasudil in Ischemic Stroke. Stroke. 2025 Aug;56(8):2306-2317. doi: 10.1161/STROKEAHA.125.050977. Epub 2025 May 27. PMID: 40421536.

Kalra A, Wilcox C, Liu W, Feng SN, Brown P, Kim BS, Brodie D, Whitman GJR, Cho SM; Hopkins Exploration, Research, and Advancement in Life support Devices (HERALD) Group. Pulse Oximetry and Arterial Blood Gas Oxygen Saturation Discrepancies and Mortality in Extracorporeal Cardiopulmonary Resuscitation Patients: An Extracorporeal Life Support Organization Registry Analysis. Crit Care Med. 2025 Aug 1;53(8):e1610-e1619. doi: 10.1097/CCM.0000000000006736. Epub 2025 Jun 16. PMID: 40521994.

Kiskaddon AL, Bains S, Smith AH, Quintessenza JA, Frank S, Rodriguez-Fazzi G, Kartha VM. Caudal Anaesthesia: clonidine and morphine dosing and outcomes in paediatric cardiac surgery. Cardiol Young. 2025 Jul 3:1-4. doi: 10.1017/S1047951125100620. Epub ahead of print. PMID: 40605632.

Lau BD, Bhave A, Yui JC, Naik R, Dane KE, Lindsley J, Shaffer DL, Kraus PS, Hoyer EH, Haut ER, Streiff MB. Inaccuracies of venous thromboembolism risk assessment and prevention practices among medically ill patients. Blood Adv. 2025 Aug 12;9(15):3929-3936. doi: 10.1182/bloodadvances.2024015306. PMID: 40408310; PMCID: PMC12336698.

Leng A, Rando H, Shah M, Akbar A, Shou B, Kalra A, Cho SM, Whitman GJR; HERALD Investigators. Re-evaluating the association between thrombocytopenia and bleeding in extracorporeal membrane oxygenation (ECMO). Perfusion. 2025 Jul 30:2676591251364481. doi: 10.1177/02676591251364481. Epub ahead of print. PMID: 40737699.

Nelson SE, Weiner C, Hua J, Sair HI, Suarez JI, Stevens RD. Connectome reorganization and functional recovery after subarachnoid hemorrhage. J Stroke Cerebrovasc Dis. 2025 Sep;34(9):108406. doi: 10.1016/j.jstrokecerebrovasdis.2025.108406. Epub 2025 Jul 23. PMID: 40712956.

Prabhakar H, Lele AV, Kapoor I, Mahajan C, Shrestha GS, Rao CV, Suarez JI, Livesay SL, Shafiq F, Popugaev K, Santosa D, Zada ON, Yang W, Nisha HA, Mijangos-Mendez JC, Agaba PK, Portilla JLP, Tuahir YH, Shanmugam P, Arruebarrena YP, Videtta W, Vásquez-García S, Raheem MSA, Yimer F, Padayachy LC, Naranjo LS, Arriaga P, Myei C, Matuja SS, Fadalla T, Viarasilpa T, Lundeg G, Salisu-Kabara HM, Tsan SEH, Gutierrez SP, Yankae LP, Konkayev A, Chaikittisilpa N, Sampaio G, Van Bui T, Mariano GSL, Sabillon GA, Blanco P, Ortiz W, Gallardo AJL, Arun O, Mani K. Neurocritical Care Organization in the Low-Income and Middle-Income Countries. Neurocrit Care. 2025 Aug;43(1):141-156. doi: 10.1007/s12028-025-02210-7. Epub 2025 Feb 7. PMID: 39920547.

Ran KR, Liu J, Vattipally VN, Cook R, Ranganathan S, Jo J, Gorbachev J, Williams JR, Rincon-Torroella J, Haut ER, Suarez JI, Huang J, Bettegowda C, Byrne JP, Azad TD. Association between cranial surgery and mortality among patients with firearm-related traumatic brain injury resulting in subdural hematoma. J Neurosurg. 2025 Jun 27:1-7. doi: 10.3171/2025.3.JNS242450. Epub ahead of print. PMID: 40577854.

Riggs BJ, Hwang M, Cohen JS, Barton K, Thimm MA, Hunt MF, Trimboli-Heidler C, Valvano TJ, Kraus CL, Dean NP, Tekes A. Ophthalmic ultrasonography can identify retinal injury associated with abusive head trauma more quickly and accurately than other neuroimaging modalities. Child Abuse Negl. 2025 Jul;165:107474. doi: 10.1016/j.chiabu.2025.107474. Epub 2025 Apr 29. PMID: 40306202.

Shah VA, Humayun M, Radzik B, Healy R, Palmisano C, Anderson-White M, Calvillo E, Geocadin R, Brown C 4th, Hogue C, Ziai W, Cho SM, Suarez JI, Rivera-Lara L. Early Relative Hypotension Below Noninvasive Cerebral Oximetry-Derived Optimal Blood Pressure Thresholds in Aneurysmal Subarachnoid Hemorrhage: A Pilot Study. Crit Care Med. 2025 Aug 19. doi: 10.1097/CCM.0000000000006826. Epub ahead of print. PMID: 40826499.

Sieber F, Alzahrani MK, Xue QL, Varadhan R, Laskow T, Brown C, Buta B, Oni J, Liu F, Walston J, Bandeen-Roche K. A taxonomy to characterize stressor variation in studies of physical resilience and its illustration in total knee replacement. J Gerontol A Biol Sci Med Sci. 2025 Jul 24;80(8):glaf151. doi: 10.1093/gerona/glaf151. PMID: 40668226; PMCID: PMC12340718.

Vallabhaneni N, Jaffray J, Branchford BR, Betensky M, Stillings A, Krava E, Alleyne MM, Ashour D, Goldenberg NA, Sochet AA. Thromboprophylaxis for Critically Ill Adolescents: A Multicenter Case-Control Study From the Children’s Healthcare Advancements in Thrombosis Consortium. Pediatr Crit Care Med. 2025 Jul 2. doi: 10.1097/PCC.0000000000003788. Epub ahead of print. PMID: 40601352.

van Vliet R, van Meenen DMP, Robba C, Cinotti R, Asehnoune K, Stevens RD, Battaglini D, Taran S, van der Jagt M, Taccone FS, Paulus F, Schultz MJ; ENIO investigators. Association of age with extubation failure in neurocritical intensive care unit patients–Insight from an international prospective study named ENIO. J Crit Care. 2025 Aug;88:155067. doi: 10.1016/j.jcrc.2025.155067. Epub 2025 Apr 3. PMID: 40184992.

Vattipally VN, Ran KR, Mukherjee D, Suarez JI, Huang J, Bettegowda C, Haut ER, Sakran JV, Witiw C, Gomez D, Azad TD, Byrne JP. Operative neurosurgery for traumatic subdural hematoma: association between trauma center variation and patient outcomes. J Neurosurg. 2025 Jul 25:1-11. doi: 10.3171/2025.3.JNS242811. Epub ahead of print. PMID: 40712171.

Vattipally VN, Ran KR, Myneni S, Liu J, Jo J, Mukherjee D, Suarez JI, Haut ER, Sakran JV, Huang J, Bettegowda C, Byrne JP, Azad TD. Interhospital Variation in Operative Intervention for Firearm-Related Penetrating Traumatic Brain Injury and Associations With Inpatient Mortality. Neurosurgery. 2025 Jul 17. doi: 10.1227/neu.0000000000003623. Epub ahead of print. PMID: 40673687.

Vattipally VN, Aude CA, Ran KR, Das O, Giwa GA, Rincon-Torroella J, Xu R, Byrne JP, Muehlschlegel S, Suarez JI, Mukherjee D, Huang J, Azad TD, Bettegowda C. Care intensity associated with sociodemographic factors without influencing inpatient mortality for patients with severe traumatic brain injury receiving palliative care. J Clin Neurosci. 2025 Jul 12;139:111479. doi: 10.1016/j.jocn.2025.111479. Epub ahead of print. PMID: 40652890.

Vattipally VN, Ran KR, Das O, Aude CA, Giwa GA, Rincon-Torroella J, Xu R, Byrne JP, Muehlschlegel S, Suarez JI, Mukherjee D, Huang J, Azad TD, Bettegowda C. Latent Variable Analysis of Demographic and Clinical Drivers of Care Intensity Before Palliative Care Consultation Among Older Adult Patients with Traumatic Brain Injury. Neurocrit Care. 2025 Aug;43(1):195-203. doi: 10.1007/s12028-024-02203-y. Epub 2025 Jan 16. PMID: 39821567.

Woldehana NA, Jung A, Parker BC, Coker AM, Haut ER, Adrales GL. Clinical Outcomes of Laparoscopic vs Robotic-Assisted Cholecystectomy in Acute Care Surgery. JAMA Surg. 2025 Jul 1;160(7):755-762. doi: 10.1001/jamasurg.2025.1291. PMID: 40397430; PMCID: PMC12096326.

Editorials, Literature Reviews and Technical Guides

Angulo SL, Johnson TW, Hutchinson L, Bhende B, Akbari Y, Cho SM, Khan IR. Inflammation and Neurological Outcomes in Cardiac Arrest – a Narrative Review of Serum Biomarker Investigations. J Intensive Care Med. 2025 Jul 13:8850666251357536. doi: 10.1177/08850666251357536. Epub ahead of print. PMID: 40653818.

Bernhardt AM, Blumer V, Vandenbriele C, Schrage B, Mody K, Pappalardo F, Silvestry S, Anderson M, Abraham J, Gage A, Goldstein D, Grant M, Klipa I, Schlöglhofer T, Lim S, Moller J, Panholzer B, Molina E, Riebandt J, Uriel N, Carnicelli A, Potapov E, Kanwar M. Clinical management of the Impella 5.5 pump. J Heart Lung Transplant. 2025 Jun 24:S1053-2498(25)02035-2. doi: 10.1016/j.healun.2025.06.008. Epub ahead of print. PMID: 40571169.

Bishara A, Kathuria A, Geocadin RG. The Gordian challenge of selective vulnerability in post-cardiac arrest brain injury: the problem or the solution? Resuscitation. 2025 Jul;212:110636. doi: 10.1016/j.resuscitation.2025.110636. Epub 2025 May 8. PMID: 40348356.

Bradshaw A, Bradshaw JC, Quinn R, Briscoe JB, Lawton JS. 80 Years After the First Blalock-Thomas-Taussig Shunt: Cardiac Research in Canines That Saved Lives. J Surg Res. 2025 Aug;312:252-262. doi: 10.1016/j.jss.2025.06.003. Epub 2025 Jul 7. PMID: 40627999.

Cha S, Kelly C, Anderson KL. Cardiopulmonary Resuscitation. Crit Care Clin. 2025 Jul;41(3):481-495. doi: 10.1016/j.ccc.2025.02.003. Epub 2025 Apr 12. PMID: 40484616.

Cohen SP, Wang EJ, Roybal A, Chen Y. Factors predicting outcomes from chronic pain management interventions. BMJ Med. 2025 Jul 7;4(1):e001143. doi: 10.1136/bmjmed-2024-001143. PMID: 40735511; PMCID: PMC12306485.

Devlin K, Ansari J, Mathur R, Shah V, Pantelyat A, Suarez JI. Role of Music Therapy in Neurocritical Care for Patients with Acute Brain Injury with Disorders of Consciousness: A Narrative Review and Proposed Framework for Practice. Neurocrit Care. 2025 Aug 6. doi: 10.1007/s12028-025-02332-y. Epub ahead of print. PMID: 40770584.

Dixit K, John L, Bora H, Hansda A, Saha B, Chakrabarti R, Dogra N, Shukla PC, Mukherjee G, Dhara S. Immunological and wound healing properties of keratin and its conformational variants extracted from ethically derived bio-resources. J Mater Chem B. 2025 Jul 21. doi: 10.1039/d5tb00029g. Epub ahead of print. PMID: 40686025.

Donovan J, Cresswell FV, Tucker EW, Davis AG, Rohlwink UK, Huynh J, Solomons R, Seddon JA, Bahr NC, van Laarhoven A, Anderson ST, Jain SK, Chow FC, Pattison S, Scriven JE, Singh G, Aarnoutse RE, Alffenaar JC, Dian S, Manesh A, Basu Roy R, Singh V, van Toorn R, Upton CM, van Crevel R, Dooley KE, Gibb D, Meya D, Wilkinson RJ, Rogozińska E, Misra UK, Figaji A, Thwaites GE. A clinical practice guideline for tuberculous meningitis. Lancet Infect Dis. 2025 Aug 18:S1473-3099(25)00364-0. doi: 10.1016/S1473-3099(25)00364-0. Epub ahead of print. PMID: 40840485.

Froyshteter AB, Lazar A, Holman AE, Frawley G, Whitaker EE. Error Traps in Infant Spinal Anesthesia. Paediatr Anaesth. 2025 Aug;35(8):598-606. doi: 10.1111/pan.15132. Epub 2025 May 30. PMID: 40444570.

Goeddel LA, Bartels K. Perioperative Monitoring: Beyond Arterial Blood Pressure and Beyond the Operating Room. Anesth Analg. 2025 Jul 1;141(1):1-3. doi: 10.1213/ANE.0000000000007534. Epub 2025 May 22. PMID: 40403179; PMCID: PMC12170153.

Hoydonckx Y, Feoktistov A, Amoozegar F, Anderson CC, Barad M, Burke E, Chitsantikul P, Doshi TL, Englesakis M, Goel A, Gupta H, Kissoon N, Kirschner A, Kohan L, Lauritsen CG, Miller F, Monsour D, Nader A, Ogunlaja O, Schuster N, Schwenk ES, Silberstein SD, Souza D, Yuan H, Narouze S. Practice advisory for intravenous management of headache disorders in hospitalized patients: a review of the evidence and consensus recommendations. Reg Anesth Pain Med. 2025 Jul 2:rapm-2025-106718. doi: 10.1136/rapm-2025-106718. Epub ahead of print. PMID: 40602807.

Hoogma DF, Meeusen I, Coppens S, Verbrugghe P, van den Eynde J, Engelman DT, Grant MC, Stoppe C, Rex S. Efficacy of enhanced recovery programmes for cardiac surgery: a systematic review and meta-analysis. Br J Anaesth. 2025 Jul;135(1):31-39. doi: 10.1016/j.bja.2025.03.019. Epub 2025 Apr 25. PMID: 40287362.

Hu EXY, van Hoorn ES, Retel Helmrich IRA, Muehlschlegel S, Rietjens JAC, Lingsma HF. Facilitators and Barriers of the Use of Prognostic Models for Clinical Decision Making in Acute Neurologic Care: A Systematic Review. Med Decis Making. 2025 Aug;45(6):753-770. doi: 10.1177/0272989X251343027. Epub 2025 Jun 29. PMID: 40581849; PMCID: PMC12260205.

Jung HS, Schatman ME, Liongson FAZ, Kritzer MD, Yong RJ, Davis D, Kaye AD, Lee KWK, Issa M, Crowther JE, Bianco GL, Christo PJ, Robinson CL. Mobile Health and Gamification of Chronic Pain Management: A Narrative Review. Curr Pain Headache Rep. 2025 Jul 31;29(1):105. doi: 10.1007/s11916-025-01416-w. PMID: 40742413.

Kemper E, Fackler J. The Time is Now. Pediatr Crit Care Med. 2025 Aug 1;26(8):e1060-e1062. doi: 10.1097/PCC.0000000000003787. Epub 2025 Jul 1. PMID: 40590638.

Kitano T, Salmon DA, Dudley MZ, Saldanha IJ, Thompson DA, Engineer L. A Systematic Review and Meta-Analysis of Health-State Utility Values for Infectious Diseases With Pandemic Potential and Associated Vaccine Adverse Reactions. Value Health. 2025 Aug;28(8):1280-1287. doi: 10.1016/j.jval.2025.02.007. Epub 2025 Mar 4. PMID: 40049326.

Mintz CD, Vutskits L. Neural Network Dynamics of Postoperative Delirium: Is It All about Neurons Striking the Right Balance? Anesthesiology. 2025 Sep 1;143(3):496-498. doi: 10.1097/ALN.0000000000005610. Epub 2025 Aug 12. PMID: 40793801.

Morales Castro D, Al-Fares AA, Paternoster G, Lyster H, Hohlfelder B, Arias Ortiz J, Abdul-Aziz MH, Herr D, Alraish R, Ferre Contreras A, Palavecino M, Milella L, Watt K, Alkazemi A, Carini FC, Roberts JA, Riera Del Brio J, Pau Parra A, Kakar V, Dureau P, Duceppe MA, Alm M, Cha S, Shekar K, Dzierba AL; Extracorporeal Membrane Oxygenation Pharmacology Network (ECMOPharm Net). Pharmacological Research Agenda on Adult Extracorporeal Membrane Oxygenation Using the Delphi Method: A Position Article of the Extracorporeal Membrane Oxygenation Pharmacology Network. Crit Care Med. 2025 Jul 30. doi: 10.1097/CCM.0000000000006806. Epub ahead of print. PMID: 40736325.

Nepogodiev D, Picciochi M, Ademuyiwa A, Adisa A, Agbeko AE, Aguilera ML, Agyei F, Alexander P, Henry J, Anyomih TTK, Aregawi AB, Atun R, Biccard B, Chalwe M, Chu K, Coomarasamy A, Crawford R, Darzi A, Davies J, Gathuya Z, George C, Ghaffar A, Ghosh D, Glasbey JC, Haque PD, Harrison EM, Hesse A, Allen Ingabire JC, Kamarajah

Nyquist P, Bhende B. The Mellow Dampening of Febrile Insanity. Crit Care Med. 2025 Jul 1;53(7):e1498-e1500. doi: 10.1097/CCM.0000000000006674. Epub 2025 Apr 10. PMID: 40207987.

Ong B, Conda LE, Mendoza TP, Hernandez AV, Cho SM. Sex differences on cerebrovascular complications in hospitalized COVID-19 patients: a meta-analysis. J Stroke Cerebrovasc Dis. 2025 Aug;34(8):108377. doi: 10.1016/j.jstrokecerebrovasdis.2025.108377. Epub 2025 Jun 13. PMID: 40518033.

Pronovost PJ, Austin JM, Milstein A. To Err Is Human: Failing to Reduce Overall Harm Is Inhumane. Am J Med Qual. 2025 Jul-Aug 01;40(4):199-201. doi: 10.1097/JMQ.0000000000000250. Epub 2025 Apr 25. PMID: 40279211.

Provenzano DA, Hanes M, Hunt C, Benzon HT, Grider JS, Cawcutt K, Doshi TL, Hayek S, Hoelzer B, Johnson RL, Kalagara H, Kopp S, Loftus RW, Macfarlane AJR, Nagpal AS, Neuman SA, Pawa A, Pearson ACS, Pilitsis J, Sivanesan E, Sondekoppam RV, Van Zundert J, Narouze S. ASRA Pain Medicine consensus practice infection control guidelines for regional anesthesia and pain medicine. Reg Anesth Pain Med. 2025 Jul 17:rapm-2024-105651. doi: 10.1136/rapm-2024-105651. Epub ahead of print. PMID: 39837579.

Rohn MCH, Simeone JM, Doctorman S, Ge P, Hernandez A, Das S, Spann M, Dow M, Segars J, Singh B. The Functional Role of Cumulus Cells and Their Influence on Oocyte Quality: A Systematic Review. Reprod Sci. 2025 Aug 6. doi: 10.1007/s43032-025-01940-5. Epub ahead of print. PMID: 40768027.

Schwengel D, Gangadharan M, Chilson K, Choi E, Weinhold A, Widing A, Binstock W, Greenberg R, Diaz C. Anesthesiologists, An Overlooked Resource: An Exposé on Anesthesiologists as Leaders in Disaster Preparedness and Response. Disaster Med Public Health Prep. 2025 Jul 21;19:e198. doi: 10.1017/dmp.2025.10124. PMID: 40686050.

SK, Karekezi C, Kruger D, Lapitan MC, Latif A, Lawani I, Ledda V, Li E, Linder C, Makasa E, Martin J, Maswime S, Mathai S, Meara JG, Mudede-Moffat F, Ntirenganya F, Park KB, Phelan LN, Pramesh CS, Ramos-De la Medina A, Raykar N, Rivello R, Roslani AC, Roy N, Samad L, Shrime M, Sobhy S, Sullivan R, Tabiri S, Tangi V, Tissingh E, Weiser TG, Williams O, Bhangu A. Surgical health policy 2025-35: strengthening essential services for tomorrow’s needs. Lancet. 2025 Aug 23;406(10505):860-880. doi: 10.1016/S0140-6736(25)00985-7. Epub 2025 Jul 14. PMID: 40675172.

Suleman MI, Essuman AA, Dada M, Williams K. The Johns Hopkins multidisciplinary pediatric pain management service: a concept paper. Pain Manag. 2025 Jul 13:1-7. doi: 10.1080/17581869.2025.2532356. Epub ahead of print. PMID: 40653781.

Veeramani A, Antonik L, Kent A. Time-sensitive surgery: the devil’s in the details. Trauma Surg Acute Care Open. 2025 Jun 23;10(2):e001920. doi: 10.1136/tsaco-2025-001920. PMID: 40557262; PMCID: PMC12186054.

Education and Quality Improvement

Chernishof V, Nour S, Chen SE, Na YB, Prichett L, Vanderhoek SM. Safe Selection: A Multi-Center Analysis of Exclusion Criteria in Pediatric Ambulatory Surgery Centers. Paediatr Anaesth. 2025 Aug 14. doi: 10.1111/pan.70037. Epub ahead of print. PMID: 40810702.

Grant MC, Brudney CS, Hernandez-Montfort J, Ibekwe SO, Rea A, Stoppe C, Zarbock A, Shaw AD, Engelman DT, Kanwar MK; PeriOperative Quality Initiative (POQI) and the Enhanced Recovery After Surgery (ERAS) Cardiac Society workgroup. Definitions of Cardiogenic Shock and Indications for Temporary Mechanical Circulatory Support: Joint Consensus Report of the PeriOperative Quality Initiative and the Enhanced Recovery After Surgery Cardiac Society. Ann Thorac Surg. 2025 Aug;120(2):202-212. doi: 10.1016/j.athoracsur.2025.01.040. Epub 2025 Apr 3. PMID: 40187589.

Grant MC, Kanwar MK, Spelde AE, Chatterjee S, Deschamps J, Arora RC, Shaw AD, Engelman DT; PeriOperative Quality Initiative (POQI) and the Enhanced Recovery After Surgery (ERAS) Cardiac Society workgroup. Temporary Mechanical Circulatory Support in Cardiogenic Shock: Executive Summary of the Joint Consensus Reports of the PeriOperative Quality Initiative and the Enhanced Recovery After Surgery Cardiac Society. Ann Thorac Surg. 2025 Aug;120(2):194-201. doi: 10.1016/j.athoracsur.2025.03.024. Epub 2025 Apr 2. PMID: 40185355.

Greene JA, Merritt MW, Paina L, Bucic SB, Dalesio N, Hanley C, Mediate E, Wadhwa S, Alfonzo Horowitz M, Gately UE, Tharp M, Singh H; PASS-UP Working Group. A Pragmatic Approach to Streamlining Single-Use Plastics in Health Care. Ann Intern Med. 2025 Aug;178(8):1192-1194. doi: 10.7326/ANNALS-25-01264. Epub 2025 Jun 24. PMID: 40550138.

LaRosa JM, Lenker H, Azamfirei R, Morgenstern S, Hajnik K, Mennie C, Wieczorek B, Brown KM, Shilkofski N, Kudchadkar SR. Development and evaluation of a simulation-based early-mobility curriculum for paediatric intensive care nurses. Nurs Crit Care. 2025 Jul;30(4):e13215. doi: 10.1111/nicc.13215. Epub 2025 Jan 6. PMID: 39763212; PMCID: PMC12221824.

Health Environment and Equity

Ariyo P, Lee SW, Latif A, Egbuta C, Pandian V, Bankole O, Desalu I, Sampson J, Winters B. Development, implementation, and evaluation of a rapid response system at a Nigerian teaching hospital, a novel idea in sub-Saharan Africa. Front Med (Lausanne). 2025 Jul 9;12:1583470. doi: 10.3389/fmed.2025.1583470. PMID: 40703286; PMCID: PMC12283680.

Clift CL, Blaser MC, Bartoli-Leonard F, Schlotter F, Higashi H, Kuraoka S, Kasai T, Turner ME, Pham T, Perez KA, Robson SC, Body SC, Muehlschlegel JD, Aikawa M, Singh SA, Aikawa E. Sexual Dimorphism of Plasma and Tissue Proteomes in Human Calcific Aortic Valve Stenosis Pathogenesis. Arterioscler Thromb Vasc Biol. 2025 Aug 14. doi: 10.1161/ATVBAHA.125.322560. Epub ahead of print. PMID: 40808650.

Feng SN, Diaz-Cruz C, Cinotti R, Asehnoune K, Schultz MJ, Shrestha GS, Sanches PR, Robba C, Cho SM; ENIO collaborators. Impact of Country Income Level on Outcomes in Patients with Acute Brain Injury Requiring Invasive Mechanical Ventilation: A Secondary Analysis of the ENIO Study. Neurocrit Care. 2025 Aug;43(1):243-253. doi: 10.1007/s12028-024-02198-6. Epub 2025 Jan 7. PMID: 39776347.

Lin C, Baldwin E, Breedlove A, Goode J, Scott PW, O’Donnell JM. Scalpel-bougie surgical airway simulation workshop for nurse anesthesia students—Focused curriculum with structured assessment. Clinical Simulation in Nursing, 2025 Aug 25; Version 106, 2025-101800. Doi: 10.1016/j.ecns.2025.101800. Epub 2025 Aug 25. Epub ahead of print.

Jeong H, Park SH, Choo YH, Kang DW, Kim YS, Yang BSK, Choi HA, Cho SM, Ha EJ, Oh J, Jeong HG; Neurocritical Care Alliance for Research and Trials – Korea (NCART-KR). Epidemiological Patterns and Variability in Acute Brain Injury: A Multicenter Registry Analysis in South Korea’s Neurocritical Care Units. Neurocrit Care. 2025 Jul 22. doi: 10.1007/s12028-025-02313-1. Epub ahead of print. PMID: 40696061.