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Selected Publications

NCBI: https://www.ncbi.nlm.nih.gov/sites/myncbi/yun.guan.1/bibliography/47480480/public/?sort=date&direction=ascending

  1. Guan Y, Borzan J, Meyer RA, Raja SN. Windup in dorsal horn neurons is modulated by endogenous spinal μ-opioid mechanisms. J. Neurosci. 2006: 26(16): 4298-4307. Co-corresponding author.
  2. Guan Y, Johanek LM, Hartke TV, Shim B, Tao YX, Ringkamp M, Meyer RA, Raja SN. Peripherally acting mu-opioid receptor agonist attenuates neuropathic pain in rats after L5 spinal nerve injury. Pain. 2008; 138(2):318-329. Co-Corresponding author.
  3. Seal RP, WangX, Guan Y, Raja SN, Woodbury CJ, Basbaum AI, Edwards RH. Unmyelinated low threshold mechanoreceptors are required for injury-induced mechanical hypersensitivity. Nature. 2009; 462 (7273): 651-655.
  4. Liu Q, Tang Z, Surdenikova L, Kim S, Patel KN, Kim A, Ru F, Guan Y, Weng HJ, Geng Y, Undem BJ, Kollarik M, Chen ZF, Anderson DJ, Dong X. Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus. Cell. 2009; 139(7): 1353-1365.
  5. Guan Y, Liu Q, Tang Z, Raja SN, Anderson DJ, Dong X. Mas-related G-protein-coupled receptors inhibit pathological pain in mice. Proc. Natl. Acad. Sci. U. S. A, 2010; 107 (36): 15933-15938.
  6. Guan Y, Wacnik PW, Yang F, Carteret AF, Chung CY, Meyer RA, Raja SN. Spinal cord stimulation-induced analgesia: electrical stimulation of dorsal column and dorsal roots attenuates dorsal horn neuronal excitability in neuropathic rats. Anesthesiology. 2010; 113(6):1392-405. Co-corresponding author. Accompanied by an Editorial View.
  7. Han L, Ma C, Liu Q, Weng H, Cui Y, Tang Z, Kim Y, Nie H, Qu L, Patel KN, Li Z, McNeil B, He S-Q, Guan Y, Xiao B, LaMotte R, Dong X. A subpopulation of nociceptors specifically linked to itch. Nature Neuroscience. 2012; 16(2):174-182.
  8. Shechter R, Yang F, Xu Q, Cheong Y-K, He S-Q, Sdrulla A, Carteret AF, Wacnik PW, Dong X, Meyer RA, Raja SN, Guan Y. Conventional and kilohertz-frequency spinal cord stimulation produces intensity- and frequency-dependent pain inhibition in a rat model of neuropathic pain. Anesthesiology. 2013;119(2): 422-432. Featured in “This Month in Anesthesiology.” Accompanied by an Editorial View. Promoted for Press Release by American Society of Anesthesiologists (ASA) and by Pain Research Forum. https://painresearchforum.org/news/30637-spinal-cord-stimulation-promising-variation-theme
  9. He S-Q, Yang F, Perez F, Xu Q, Shechter R, Cheong YK, Carteret AF, Dong X, Sweitzer, SM, Raja SN, Guan Y. Tolerance to the anti-allodynic effects of the peripherally acting opioid, loperamide hydrochloride, develops in nerve-injured rats. Pain. 2013; 154 (11):2477-2486.
  10. He S-Q, Li Z, Chu Y-X, Han L, Xu Q, Li M, Yang F, Liu Q, Tang Z, Wang Y, Hin N, Tsukamato T, Slusher B, Tiwari V, Shechter R, Wei F, Raja SN, Dong X, Guan Y. MrgC agonism at central terminals of primary sensory neurons inhibits neuropathic pain. Pain. 2014; 155 (3):534-544.
  11. Li Z, He S-Q, Xu Q, Yang F, Tiwari V, Liu Q, Tang Z, Han L, Chu Y-X, Wang Y, Hin N, Tsukamato T, Slusher B, Guan X, Wei F, Raja SN, Dong X, Guan Y. Activation of MrgC receptor inhibits N-type calcium channels in small-diameter primary sensory neurons in mice. Pain. 2014; 155 (8):1613-1621.
  12. Weng H, Patel KN, Jeske NA, Bierbower SM, Zou W, Tiwari V, Zheng Q, Tang Z, Mo G, Wang Y, Geng Y, Zhang J, Guan Y, Akopian A, Dong X. Tmem100 is a regulator of TRPA1-TRPV1 complex and contributes to persistent pain. Neuron. 2015; 85(4):833-846.
  13. Sdrulla AD, Xu Q, He S-Q, Tiwari V, Yang F, Zhang C, Shechter R, Raja SN, Wang Y, Dong X, Guan Y. Electrical stimulation of low-threshold afferent fibers induces a prolonged synaptic depression in lamina II dorsal horn neurons to high-threshold afferent inputs in mice. Pain. 2015; 156(6):1008-1017.
  14. Tiwari V, Yang F, He S-Q, Shechter R, Zhang C, Shu B, Zhang T, Tiwari V, Wang Y, Dong X, Guan Y, Raja SN. Activation of Peripheral μ-opioid Receptors by Dermorphin [D-Arg2, Lys4] (1-4) Amide Leads to Modality-preferred Inhibition of Neuropathic Pain. Anesthesiology. 2016; 124(3):706-720. Co-corresponding author.
  15. Yang F, Xu Q, Shu B, Tiwari V, He SQ, Vera-Portocarrero LP, Dong X, Linderoth B, Raja SN, Wang Y, Guan Y. Activation of cannabinoid CB1 receptor contributes to suppression of spinal nociceptive transmission and inhibition of mechanical hypersensitivity by Aβ-fiber stimulation. Pain. 2016; 157(11):2582-2593.
  16. Kim YS, Anderson M, Park K, Zheng Q, Agarwal A, Gong C, Saijilafu Young L, He S-Q, LaVinka PC, Zhou F, Bergles D, Hanani M, Guan Y, Spary DC, Dong X. Coupled activation of primary sensory neurons contributes to chronic pain. Neuron. 2016; 91(5):1085-1096.
  17. Sun SH, Xu Q, Guo C, Guan Y, Liu Q, Dong X. Leaky gate model: intensity-dependent coding of pain and itch in spinal cord. Neuron. 2017; 93(4):840-853.
  18. Li Z, Tseng P-Y, Tiwari V, Xu Q, He SQ, Wang Y, Zheng Q, Han L, Wu Z, Blobaum AL, Cui Y, Tiwari V, Sun S, Cheng Y, Huang-Lionnet J, Geng Y, Xiao B, Peng J, Hopkins CR, Raja SN, Guan Y, Dong X. Targeting human Mas-related G-protein–coupled receptor X1 to inhibit persistent pain. Proc. Natl. Acad. Sci. U. S. A. 2017; 114(10): 1996-2005. Co-corresponding author.
  19. Yang F, Anderson M, He S, Stephens K, Zheng Y, Chen ZY, Raja SN, Aplin, F, Guan Y, Fridman G. Differential expression of voltage-gated sodium channels in afferent neurons renders selective neural block by ionic direct current. Science Advances. 2018; Apr 11;4(4):eaaq1438. doi: 10.1126/sciadv.aaq1438. Co-corresponding author.
  20. Tiwari V, Anderson M, Yang F, Tiwari V, Zheng Q, He S-Q, Zhang T, Shu B, Chen XM, Grenald S, Stephens K, Chen Z, Dong X, Raja SN, Guan Y. Peripherally Acting μ-Opioid Receptor Agonists Attenuate Ongoing Pain-associated Behavior and Spontaneous Neuronal Activity after Nerve Injury in Rats. Anesthesiology. 2018 Jun; 128(6):1220-1236.
  21. He SQ, Xu Q, Tiwari V, Yang, F, Anderson M, Chen ZY, Grenald S., Raja SN, Dong X, Guan Y. Oligomerization of MrgC11 and μ-opioid Receptors in Sensory Neurons Enhances Morphine Analgesia. Science Signaling. 2018 Jun 19;11(535). pii: eaao3134. doi: 10.1126/scisignal.aao3134.
  22. Stephens K, Chen Z, Sivanesan E, Raja SN, Linderoth B, Taverna SD, Guan Y. RNA-seq of Spinal Cord from Nerve-injured Rats after Spinal Cord Stimulation. Molecular Pain. 2018 Jan-Dec;14:1744806918817429. doi: 10.1177/1744806918817429. Epub 2018 Nov 19.
  23. Zhu S, Zhu J, Zhen G, Hu Y, An S, Li Y, Zheng Q, Chen Z, Yang Y, Wan M, Skolasky RL, Cao Y, Wu T, Gao B, Yang M, Gao M, Kuliwaba J, Ni S, Wang L, Wu C, Findlay D, Eltzching HK, Ouyang HW, Crane J, Zhou FQ, Guan Y, Dong X, Cao X. Subchondral one osteoclasts induce sensory innervation and osteoarthritis pain. Journal Clinical Investigation. 2018; Dec 11. pii: 121561. doi: 10.1172/JCI121561
  24. Yang F, Duan WR, Huang Q, Chen Z, Ford N, Gao X, Sivanesan E, Sarma SV, Vera-Portocarrero LP, Linderoth B, Raja SN, Guan Y. Modulation of spinal nociceptive transmission by sub-sensory threshold spinal cord stimulation in rats after nerve injury. Neuromodulation. 2019 Jun 4. doi: 10.1111/ner.12975. [Epub ahead of print]
  25. Tiwari V, Tiwari V, He S-Q, Zhang T, Raja SN, Dong X, Guan Y. Mas-related G protein-coupled receptors offer potential new targets for pain therapy. Adv Exp Med Biol. 2016; 904:87-103.
  26. Chakravarthy K, Richter H, Christo PJ, Williams K, Guan Y. Spinal cord stimulation for treating chronic pain: Reviewing preclinical and clinical data on paresthesia-free high-frequency therapy. Neuromodulation. 2018 Jan;21(1):10-18.
  27. Sivanesan E, Maher D, Raja SN, Linderoth B, Guan Y. Supraspinal Mechanisms of Spinal Cord Stimulation for Modulation of Pain: Five Decades of Research and Prospects for the Future. Anesthesiology. 2019 Apr;130(4):651-665.
  28. Liu S, Huang Q, He S, Chen Z, Gao X, Ma D, Duan W, Ford N, Yang F, Chen X, Raja SN, Hao D, Guan Y. Dermorphin [D-Arg2, Lys4] (1-4) amide inhibits below-level heat hypersensitivity in mice after contusive thoracic spinal cord injury. Pain. 2019 Jul 29. doi: 10.1097/j.pain.0000000000001671.
  29. Raja SN, Sivanesan E, Guan Y. Central Sensitization, N-methyl-D-aspartate Receptors, and Human Experimental Pain Models: Bridging the Gap between Target Discovery and Drug Development. Anesthesiology. 2019 Aug;131(2):233-235. doi: 10.1097/ALN.0000000000002808.
  30. Sivanesan E, Stephens KE, Huang Q, Chen Z, Ford N, Duan W, He S, Gao X, Linderoth B, Raja SN, Guan Y. Spinal Cord Stimulation Prevents Paclitaxel-induced Mechanical and Cold Hypersensitivity and Modulates Spinal Gene Expression in Rats. Pain Reports. 2019 Sept. [Epub ahead of print]

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