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Publications

Dr. Lee-Summers’ research has been published in a variety of journals and publications:[/wr_text][wr_accordion #_EDITTED el_title=”” div_margin_top=”0″ div_margin_left=”0″ div_margin_bottom=”25″ div_margin_right=”0″ initial_open=”0″ multi_open=”no” filter=”no” appearing_animation=”0″ css_suffix=”” id_wrapper=”” disabled_el=”no” wrapper_padding_top=”0″ wrapper_padding_left=”0″ wrapper_padding_bottom=”0″ wrapper_padding_right=”0″ wrapper_bg_color=”” wrapper_bg_opacity_slider=”” wrapper_bg_opacity=”100″ wrapper_border_top=”0″ wrapper_border_left=”0″ wrapper_border_bottom=”0″ wrapper_border_right=”0″ wrapper_border_style=”solid” wrapper_border_color=”” wrapper_rounded_topleft=”0″ wrapper_rounded_topright=”0″ wrapper_rounded_bottomleft=”0″ wrapper_rounded_bottomright=”0″ responsive_hide=”no” ][wr_item_accordion heading=”CELL DEATH RESEARCH ” icon=”” tag=”” disabled_el=”no” ]

  1. Wang B, Armstrong JS, Lee JH, Bhalala U, Kulikowicz E, Zhang E, Reyes M, Moy N, Spicer D, Zhu J, Yang ZJ, Koehler RC, Martin LJ, Lee JK. Rewarming from therapeutic hypothermia induces cortical neuron apoptosis in a swine model of neonatal hypoxic-ischemic encephalopathy. Journal of Cerebral Blood Flow and Metabolism 2015; 35(5): 781-93.
    https://journals.sagepub.com/doi/10.1038/jcbfm.2014.245
  2. Wang B, Armstrong JS, Reyes M, Kulikowicz E, Lee JH, Spicer D, Bhalala U, Yang ZJ, Koehler RC, Martin LJ, Lee JK. White matter apoptosis is increased by delayed hypothermia and rewarming in a neonatal piglet model of hypoxic ischemic encephalopathy. Neuroscience 2016; 316:296-310.
    https://pubmed.ncbi.nlm.nih.gov/26739327/
  3. Lee JK, Wang B, Reyes M, Armstrong JS, Kulikowicz E, Santos PT, Lee JH, Koehler RC, Martin LJ. Hypothermia and rewarming activate and macroglial unfolded protein response independent of hypoxic-ischemic brain injury in neonatal piglets. Dev Neurosci 2016; 38:277-294.
    https://www.karger.com/Article/Fulltext/448585
  4. Santos PT, O’Brien CE, Chen MW, Hopkins CD, Adams S, Kulikowicz E, Singh R, Koehler RC, Martin LJ, Lee JK. Proteasome biology is compromised in white matter after asphyxic cardiac arrest in neonatal piglets. J Am Heart Assoc 2018; 7: e009415.
    https://www.ahajournals.org/doi/10.1161/JAHA.118.009415
  5. O’Brien CE, Santos PT, Kulikowicz E, Reyes M, Koehler RC, Martin LJ, Lee JK. Hypoxia-ischemia and hypothermia independently and interactively affect neuronal pathology in neonatal piglets with short-term recovery. Dev Neurosci 2019.
    https://pubmed.ncbi.nlm.nih.gov/31108487/
  6. Singh R, Kulikowicz E, Santos PT, Koehler RC, Martin LJ, *Lee JK. Spatial T-maze identifies cognitive deficits in piglets 1 month after hypoxia-ischemia in a model of hippocampal pyramidal neuron loss and interneuron attrition. Behavioural Brain Research 2019.
    https://www.sciencedirect.com/science/article/pii/S0166432818315365?via=ihub
  7. Lee JK, Liu D, Raven EP, Jiang D, Liu P, Qin Q, Kulikowicz E, Santos PT, Adams S, Zhang J, Koehler RC, Martin LJ, Tekes A. Mean diffusivity in striatum correlates with acute neuronal death but not lesser neuronal injury in a pilot study of neonatal piglets with encephalopathy. J Magn Reson Imaging 2020.
    https://dx.doi.org/10.1002/jmri.27181

[/wr_item_accordion][wr_item_accordion heading=”AUTOREGULATION – CLINICAL ” icon=”” tag=”” disabled_el=”no” ]

  1. Lee JK, Poretti A, Perin J, Huisman TAGM, Parkinson C, Chavez-Valdez R, O’Connor M, Reyes M, Armstrong J, Jennings JM, Gilmore MM, Koehler RC, Northington FJ, Tekes A. Optimizing cerebral autoregulation may decrease neonatal regional hypoxic-ischemic brain injury. Dev Neurosci 2017; 39:248-256.
    https://www.karger.com/Article/Fulltext/452833
  2. Burton VJ, Gerner G, Cristofalo E, Chung SE, Jennings JM, Parkinson C, Koehler RC, Valdez RC, Johnston MV, Northington FJ, Lee JK. A pilot cohort study of cerebral autoregulation and 2-year neurodevelopmental outcomes in neonates with hypoxic-ischemic encephalopathy who received therapeutic hypothermia. BMC Neurology 2015; 15:209–22.
    https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-015-0464-4
  3. Tekes A, Poretti A, Scheurkogel MM, Huisman TAGM, Howlett JA, Alqahtani E, Lee JH, Parkinson C, Shapiro K, Chung SE, Jennings JM, Gilmore MM, Hogue CW, Martin LJ, Koehler RC, Northington FJ, Lee JK. Apparent Diffusion Coefficient Scalars Correlate with Near Infrared Spectroscopy Markers of Cerebrovascular Autoregulation in Neonates Cooled for Perinatal Hypoxic Ischemic Injury. Am J Neuroradiol 2015; 36(1):188-93.
    https://pubmed.ncbi.nlm.nih.gov/25169927/
  4. Lee JK, Brady KM, Chung SE, Jennings JM, Whitaker EE, Aganga D, Easley RB, Heitmiller K, Jamrogowicz JL, Larson AC, Lee JH, Jordan LC, Hogue CW, Lehmann CU, Bembea MM, Hunt EA, Koehler RC, Shaffner DH. A pilot study of cerebrovascular reactivity autoregulation after pediatric cardiac arrest. Resuscitation 2014; 85(10): 1387-93.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164565/
  5. Lee JK, Williams M, Reyes M, Ahn ES. Cerebrovascular blood pressure autoregulation monitoring and postoperative transient ischemic attack in pediatric moyamoya vasculopathy. Paediatr Anaesth 2018; 28: 94-102.
    https://pubmed.ncbi.nlm.nih.gov/29205668/
  6. Howlett JA, Northington FJ, Gilmore MM, Tekes A, Huisman TAGM, Parkinson C, Chung SE, Jennings JM, Jamrogowicz JJ, Larson AC, Lehmann CU, Jackson E, Brady KM, Koehler RC, Lee JK. Cerebrovascular autoregulation and neurologic injury in neonatal hypoxic-ischemic encephalopathy. Pediatr Res 2013; 74: 525-535.
    https://www.nature.com/articles/pr2013132.pdf?origin=ppub
  7. Gilmore MM, Tekes A, Perin J,, Parkinson C, Spahic H, Chavez-Valdez R, Northington FJ. Lee JK. Later cooling within 6 h and temperatures outside 33-34 °C are not associated with dysfunctional autoregulation during hypothermia for neonatal encephalopathy. Pediatric Res 2020;
    https://www.nature.com/articles/s41390-020-0876-8

[/wr_item_accordion][wr_item_accordion heading=”AUTOREGULATION – LABORATORY ” icon=”” tag=”” disabled_el=”no” ]

  1. Lee JK, Kibler KK, Benni PB, Easley RB, Czosnyka M, Smielewski P, Koehler RC, Shaffner DH, Brady KM. Cerebrovascular reactivity measured by near-infrared spectroscopy. Stroke 2009; 40(5): 1820-1826.
    https://www.ahajournals.org/doi/full/10.1161/STROKEAHA.108.536094
  2. Brady KM, Lee JK, Kibler KK, Smielewski P, Czosnyka M, Easley RB, Koehler RC, Shaffner DH. Continuous time-domain analysis of cerebrovascular autoregulatory vasoreactivity using near-infrared spectroscopy. Stroke 2007; 38(10): 2818-2825.
    https://pubmed.ncbi.nlm.nih.gov/17761921/
  3. Lee JK, Brady KM, Mytar JO, Kibler KK, Carter EL, Hirsch KG, Hogue CW, Easley RB, Jordan LC, Smielewski P, Czosnyka M, Shaffner DH, Koehler RC. Cerebral blood flow and cerebrovascular autoregulation in a swine model of pediatric cardiac arrest and hypothermia. Crit Care Med 2011; 39(10): 2337-2345.
    https://pubmed.ncbi.nlm.nih.gov/21705904/
  4. Lee JK, Yang ZJ, Bing W, Larson AC, Jamrogowicz JL, Kulikowicz E, Kibler KK, Mytar JO, Carter EL, Burman HT, Brady KM, Smielewski P, Czosnyka M, Koehler RC, Shaffner DH. Noninvasive autoregulation monitoring in a swine model of pediatric cardiac arrest. Anesth Analg 2012; 114(4): 825-836.
    https://journals.lww.com/anesthesia-analgesia/Fulltext/2012/04000/Noninvasive_Autoregulation_Monitoring_in_a_Swine.24.aspx
  5. Larson AC, Jamrogowicz JL, Kulikowicz E, Wang B, Yang ZJ, Shaffner DH, Koehler RC, Lee JK. Cerebrovascular autoregulation after rewarming from hypothermia in a neonatal swine model of asphyxic brain injury. J Appl Physiol 2013; 115(10): 1433-1442.
    https://journals.physiology.org/doi/full/10.1152/japplphysiol.00238.2013
  6. Govindan RB, Brady KM, Massaro AN, Perin J, Jennings JM, duPlessis AJ, Koehler RC, Lee JK. Comparison of frequency- and time-domain autoregulation and vasoreactivity indices in a piglet model of hypoxia-ischemia and hypothermia. Dev Neurosci 2019.
    https://www.karger.com/Article/FullText/499425
  7. Liu X, Hu X, Brady KM, Koehler RC, Smielewski P, Czosnyka M, Donnely J, Lee JK. Comparison of wavelet and correlation indices of cerebral autoregulation in a pediatric swine model of cardiac arrest. Sci Rep 2020.
    https://www.nature.com/articles/s41598-020-62435-8

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