Department of Anesthesiology and Critical Care Medicine
The Johns Hopkins University School of Medicine
720 Rutland Avenue, Ross 370B
Baltimore, MD 21205
The research of Dr. Jian Wang focuses on understanding the pathophysiology of stroke (hemorrhagic and ischemic) and traumatic brain injury. He uses established in vitro, ex vivo and in vivo models to investigate the cellular and molecular mechanisms that may contribute to such brain injury and assess potential therapeutic modalities for protecting the brain from such injury. The research tools used in his lab include cellular and molecular neurobiology, pharmacology, immunology, MRI, and neurobehavioral testing. Supported by the National Institutes of Health (NIH) and American Heart Association (AHA), his current research focuses on prostaglandin E2 receptors, natural compounds known as flavonoids, and neuronal cell death pathways. The long-term goal of his research is to reduce stroke- (hemorrhagic and ischemic) and trauma-induced brain injury and improve long-term functional outcomes.
- American Heart and Stroke Association
- American Society for Neuroscience
- International Society for Cerebral Blood Flow & Metabolism
- Wang J, Rogove AD, Tsirka AE, Tsirka SE. Protective role of Tuftsin fragment 1-3 in an animal model of intracerebral hemorrhage. Ann Neurol 54:655–664, 2003.
- Wang J, Tsirka SE. Neuroprotection by inhibition of matrix metalloproteinases in a mouse model of intracerebral hemorrhage. Brain 128:1622–33, 2005.
- Wang J, Doré S. Heme oxygenase-1 exacerbates early brain injury after intracerebral hemorrhage. Brain 130:1643–52, 2007.
- Wang J. Preclinical and clinical research on inflammation after intracerebral hemorrhage. Prog Neurobiol 92: 463-477, 2010.
- Wu H, Wu T, Xu X, Wang J, Wang J. Iron toxicity in mice with collagenase-induced intracerebral hemorrhage. J Cereb Blood Flow & Metab 31:1243–50, 2011.
- Wu H, Wu T, Li M, Wang J. Efficacy of the lipid-soluble iron chelator 2,2’-dipyridyl against hemorrhagic brain injury. Neurobiol Dis 45: 388–94, 2012.
- Wang J, Yu L, Jiang C, Chen M, Wang M, Wang J. Bone marrow mononuclear cells exert long-term neuroprotection in a rat model of ischemic stroke by promoting arteriogenesis and angiogenesis. Brain Behav Immun 34: 56–66, 2013.
- Chang CF, Cho S, Wang J. (-)-Epicatechin protects hemorrhagic brain via synergistic Nrf2 pathways. Ann Clin Transl Neurol 1: 258–271,
- Wang J, Yu L, Jiang C, Fu X, Liu X, Wang M, Ou C, Cui X, Zhou C, Wang J. Cerebral ischemia increases bone marrow CD4 CD25 FoxP3 regulatory T cells in mice via signals from sympathetic nervous system. Brain Behav Immun 43: 172–183, 2015.
- Zhao X, Wu T, Chang CF, Wu H, Han X, Li Q, Gao Y, Li Q, Hou Z, Maruyama T, Zhang J, Wang J. Toxic role of prostaglandin E2 receptor EP1 after intracerebral hemorrhage in mice. Brain Behav Immun 46: 293–310, 2015.
- Wang M, Hong X, Chang CF, Li Q, Ma B, Zhang H, Xiang S, Heo H, Zhang Y, Leigh R, Koehler R, van Zijl P, Wang J*, Zhou J*. Simultaneous detection and separation of hyperacute intracerebral hemorrhage and cerebral ischemia using amide proton transfer (APT) MRI. Magn Reson Med 74: 42–50, 2015 (*co-corresponding authors).
- Han X, Lan X, Li Q, Gao Y, Zhu W, Cheng T, Maruyama T, Wang J. Inhibition of prostaglandin E2 receptor EP3 mitigates thrombin-induced brain injury. J Cereb Blood Flow Metab 36: 1059–74, 2016.
- Cheng T, Wang W, Li Q, Han X, Xing J, Qi C, Lan X, Wan J, Potts A, Guan F, and Wang J. Cerebroprotection of (-)-epicatechin after traumatic brain injury via Nrf2–dependent and –independent pathways. Free Radic Biol Med 92: 15–28, 2016.
- Lan X, Han X, Li Qian, Li Qiang, Gao Y, Cheng T, Wan J, Zhu W, Wang J. Pinocembrin protects intracerebral hemorrhagic brain primarily by inhibiting toll-like receptor 4 and reducing M1 phenotype microglia. Brain Behav Immun 2016; in press
- Wu H, Wu T, Han X, Wan J, Jiang C, Chen W, Lu H, Yang Q, Wang J. Cerebroprotection by the neuronal PGE2 receptor EP2 after intracerebral hemorrhage in middle-aged mice. J Cereb Blood Flow Metab 37: 39–51, 2017.
- Li Q, Han X, Lan X, Gao Y, Wan J, Durham F, Cheng T, Yang J, Wang Z, Jiang C, Ying M, Koehler RC, Stockwell BR, Wang J. Inhibition of neuronal ferroptosis protects hemorrhagic brain. JCI Insight 2017; in press.
Current Laboratory Members/Key Associates
Xiaoning Han, MD, PhD
Xi Lan, PhD
Qian Li, MD, PhD
Jieru Wan, MD
Junmin Wang, PhD
- American Heart Association Postdoctoral Fellowship (2002–2004)
- American Heart Association Scientist Development Award (2006–2008)
- American Heart Association Beginning Grant-in-Aid (2009–2011)
- NIH K01 award (2008–2013)
- American Heart Association Grant-in-Aid (2013–2015)
- ACCM Research StAAR Award (2016–2017)